SOCS4 gene expression is inhibited by RUNX1

Stable Identifier
R-HSA-8955893
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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SOCS4 gene expression is inhibited by RUNX1
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RUNX1, presumably in complex with CBFB, inhibits transcription of the SOCS4 gene. As SOCS4 is an inhibitor of STAT3, RUNX1-mediated repression of SOCS4 increases STAT3 activity, which is implicated in development of epithelial cancers (Scheitz et al. 2012).

Literature References
PubMed ID Title Journal Year
23034403 Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer

Lee, TS, Tumbar, T, McDermitt, DJ, Scheitz, CJ

EMBO J. 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX1:CBFB:SOCS4 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Inferred From
Socs4 gene expression is inhibited by Runx1 (Mus musculus)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-13)
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