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RUNX1:CBFB:SOCS3 gene [nucleoplasm]
Stable Identifier
R-HSA-8955750
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
RUNX1 binds the SOCS3 gene (Homo sapiens)
RUNX1:CBFB:SOCS3 gene [nucleoplasm] (Homo sapiens)
SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)
RUNX1:CBFB:SOCS3 gene [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23034403
Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer
Lee, TS
,
Tumbar, T
,
McDermitt, DJ
,
Scheitz, CJ
EMBO J.
2012
Participants
components
RUNX1:CBFB [nucleoplasm]
(Homo sapiens)
SOCS3 gene [nucleoplasm]
(Homo sapiens)
Participates
as an output of
RUNX1 binds the SOCS3 gene (Homo sapiens)
This entity regulates
Negatively
SOCS3 gene expression is inhibited by RUNX1
(Homo sapiens)
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