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COMMD4 [cytosol]
Stable Identifier
R-HSA-8955111
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
COMM domain-containing protein 4, COMD4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H0A8 COMMD4
Gene Names
COMMD4
Chain
chain:1-199
Reference Genes
BioGPS Gene:54939 COMMD4
COSMIC (genes):COMMD4 COMMD4
CTD Gene:54939 COMMD4
dbSNP Gene:54939 COMMD4
ENSEMBL:ENSG00000140365 COMMD4
HGNC:26027 COMMD4
KEGG:hsa:54939 COMMD4
Monarch:54939 COMMD4
NCBI Gene:54939 COMMD4
OMIM:616701 COMMD4
UCSC:Q9H0A8 COMMD4
Reference Transcript
RefSeq:NM_001284378.1 COMMD4
RefSeq:NM_001284377.1 COMMD4
RefSeq:NM_017828.4 COMMD4
Other Identifiers
11716445_s_at
11756005_x_at
11762299_x_at
16803185
206441_PM_s_at
206441_s_at
209132_PM_s_at
209132_s_at
209133_PM_s_at
209133_s_at
32198_at
3600897
3600902
3600903
3602265
3602266
3602267
3602268
3602269
3602270
3602271
3602272
3602273
3602274
3602275
3602276
3602277
3602278
3602279
3602280
3602281
3602282
3602283
3602284
3602285
3602286
3602287
3602288
3602289
3602290
3602291
3602292
3602293
3602294
3602295
3602296
3602298
3632760
3632761
3632766
3634429
3634436
54939
7984989
A_14_P134408
A_23_P117767
A_24_P331904
GE499328
GE55503
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0043226
GO:0043231
HMNXSV003008854
Hs.18490.1.A1_3p_a_at
ILMN_1778562
ILMN_2096654
PH_hs_0016972
PH_hs_0040219
TC15000694.hg
g12053248_3p_a_at
g8923422_3p_a_at
Participates
as a candidate of
COMMDs [cytosol] (Homo sapiens)
Other forms of this molecule
COMMD4 [nucleoplasm]
Inferred To
COMMD4 [cytosol]
(Bos taurus)
COMMD4 [cytosol]
(Caenorhabditis elegans)
COMMD4 [cytosol]
(Canis familiaris)
COMMD4 [cytosol]
(Gallus gallus)
COMMD4 [cytosol]
(Sus scrofa)
Commd4 [cytosol]
(Mus musculus)
Commd4 [cytosol]
(Rattus norvegicus)
commd4 [cytosol]
(Dictyostelium discoideum)
commd4 [cytosol]
(Xenopus tropicalis)
CG34039-RA [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSG00000140365
,
ENSP00000457693
,
ENSP00000267935
,
ENST00000267935
,
ENST00000338995
,
ENST00000480484
,
ENSP00000433662
,
ENST00000567195
,
ENSP00000340867
OpenTargets
ENSG00000140365
GeneCards
COMMD4
HPA
ENSG00000140365-COMMD4
PRO
Q9H0A8
Pharos - Targets
Q9H0A8
PDB
8F2U
,
8F2R
,
8P0W
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.643
4
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.643
4
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