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COMMD7 [cytosol]
Stable Identifier
R-HSA-8955104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
COMM domain-containing protein 7, COMD7_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86VX2 COMMD7
Gene Names
COMMD7, C20orf92
Chain
chain:1-200
Reference Genes
BioGPS Gene:149951 COMMD7
COSMIC (genes):COMMD7 COMMD7
CTD Gene:149951 COMMD7
dbSNP Gene:149951 COMMD7
ENSEMBL:ENSG00000149600 COMMD7
HGNC:16223 COMMD7
KEGG:hsa:149951 COMMD7
Monarch:149951 COMMD7
NCBI Gene:149951 COMMD7
OMIM:616703 COMMD7
UCSC:Q86VX2 COMMD7
Reference Transcript
RefSeq:NM_001099339.1 COMMD7
RefSeq:NM_053041.2 COMMD7
Other Identifiers
11715875_a_at
149951
16918351
224815_PM_at
224815_at
3902887
3902889
3902891
3902897
56483_at
8065637
A_23_P420428
A_32_P141724
GE85403
GO:0005515
GO:0006355
GO:0016020
GO:0031410
GO:0032088
GO:0033209
GO:0043226
GO:0045892
GO:0051059
HMNXSV003036740
Hs.11197.0.S1_3p_at
ILMN_1810334
PH_hs_0028350
TC20000766.hg
Participates
as a candidate of
COMMDs [cytosol] (Homo sapiens)
Other forms of this molecule
COMMD7 [nucleoplasm]
Inferred To
Commd7 [cytosol]
(Mus musculus)
Commd7 [cytosol]
(Rattus norvegicus)
COMMD7 [cytosol]
(Bos taurus)
COMMD7 [cytosol]
(Canis familiaris)
COMMD7 [cytosol]
(Gallus gallus)
COMMD7 [cytosol]
(Sus scrofa)
commd7 [cytosol]
(Danio rerio)
commd7 [cytosol]
(Dictyostelium discoideum)
Cross References
ENSEMBL
ENSP00000278980
,
ENSP00000395339
,
ENST00000446419
,
ENST00000278980
OpenTargets
ENSG00000149600
HPA
ENSG00000149600-COMMD7
PRO
Q86VX2
Pharos - Targets
Q86VX2
PDB
8F2U
,
8P0W
,
8ESD
,
8F2R
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