Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
COMMD2 [nucleoplasm]
Stable Identifier
R-HSA-8955099
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
COMM domain-containing protein 2, COMD2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs [nucleoplasm] (Homo sapiens)
COMMD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86X83 COMMD2
Gene Names
COMMD2, HSPC042, My004
Chain
chain:1-199
Reference Genes
BioGPS Gene:51122 COMMD2
COSMIC (genes):COMMD2 COMMD2
CTD Gene:51122 COMMD2
dbSNP Gene:51122 COMMD2
ENSEMBL:ENSG00000114744 COMMD2
HGNC:24993 COMMD2
KEGG:hsa:51122 COMMD2
Monarch:51122 COMMD2
NCBI Gene:51122 COMMD2
OMIM:616699 COMMD2
UCSC:Q86X83 COMMD2
Reference Transcript
RefSeq:NM_016094.3 COMMD2
Other Identifiers
11733105_at
11733106_x_at
11733107_at
16960399
223491_PM_at
223491_at
226910_PM_at
226910_at
2700484
2700499
2700501
2700502
2700503
2700504
2700505
2700506
2700507
2700508
2700509
2700510
2700511
2700512
2700513
2700514
2700515
2700516
51122
57510_at
63836_r_at
8091432
89840_at
A_23_P40782
GE57014
GE787061
GO:0005515
GO:0005737
HMNXSV003007507
Hs.22581.0.A1_3p_at
ILMN_1683305
PH_hs_0020036
PH_hs_0037145
TC03001892.hg
g12654770_3p_at
Participates
as a candidate of
COMMDs [nucleoplasm] (Homo sapiens)
Other forms of this molecule
COMMD2 [cytosol]
Inferred To
COMMD2 [nucleoplasm]
(Bos taurus)
COMMD2 [nucleoplasm]
(Canis familiaris)
COMMD2 [nucleoplasm]
(Gallus gallus)
COMMD2 [nucleoplasm]
(Sus scrofa)
Commd2 [nucleoplasm]
(Mus musculus)
Commd2 [nucleoplasm]
(Rattus norvegicus)
Dmel\CG7168 [nucleoplasm]
(Drosophila melanogaster)
commd2 [nucleoplasm]
(Danio rerio)
commd2 [nucleoplasm]
(Dictyostelium discoideum)
commd2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000473414
,
ENSP00000419475
OpenTargets
ENSG00000114744
HPA
ENSG00000114744-COMMD2
PRO
Q86X83
Pharos - Targets
Q86X83
GlyGen
Q86X83
PDB
8P0W
,
8F2R
,
8F2U
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96PC5 MIA2
1
MIA2 [endoplasmic reticulum membrane]
(R-HSA-9637821)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text