Reactome | MZT1 [cytosol]

MZT1 [cytosol]

Stable Identifier

R-HSA-8955055

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MOZART1, Mitotic-spindle organizing protein 1, C13orf37, MZT1_HUMAN

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
        
        Association of NuMA with microtubules (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT1 [cytosol] (Homo sapiens)
        
        p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT1 [cytosol] (Homo sapiens)
        
        Translocation of NuMA to the centrosomes (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT1 [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT1 [cytosol] (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
        
        Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT1 [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q08AG7 MZT1

Gene Names

MZT1, C13orf37, MOZART1

Chain

initiator methionine:, chain:2-82

Reference Genes

BioGPS Gene:440145 MZT1

COSMIC (genes):MZT1 MZT1

CTD Gene:440145 MZT1

dbSNP Gene:440145 MZT1

ENSEMBL:ENSG00000204899 MZT1

HGNC:33830 MZT1

KEGG:hsa:440145 MZT1

Monarch:440145 MZT1

NCBI Gene:440145 MZT1

OMIM:613448 MZT1

UCSC:Q08AG7 MZT1

Reference Transcript

RefSeq:NM_001071775.2 MZT1

Other Identifiers

11725333_at

11725334_at

11725335_s_at

16779720

225578_PM_at

225578_at

3517567

3517568

3517570

3517571

3517572

3517576

3517579

440145

54333_at

A_24_P532589

A_32_P9382

GE62679

GO:0000930

GO:0000931

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0007010

GO:0031021

GO:0033566

GO:0043226

GO:0051415

GO:0090307

HMNXSV003028524

Hs.28465.1.S1_3p_at

ILMN_1809662

ILMN_2226415

PH_hs_0002490

TC13000726.hg

Participates

as a component of

gamma-tubulin complex [cytosol] (Homo sapiens)

Inferred To

MZT1 [cytosol] (Bos taurus)

MZT1 [cytosol] (Canis familiaris)

MZT1 [cytosol] (Gallus gallus)

MZT1 [cytosol] (Sus scrofa)

Ghost homologue of MZT1 [cytosol] (Xenopus tropicalis)

Mzt1 [cytosol] (Mus musculus)

Mzt1 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000377818, ENSP00000367049, ENSG00000204899

OpenTargets

ENSG00000204899

GeneCards

MZT1

HPA

ENSG00000204899-MZT1

PRO

Q08AG7

Pharos - Targets

Q08AG7

PDB

7QJ9, 7AS4, 7QJB, 8RX1, 7QJ4, 7QJ8, 7QJ6, 7QJ3, 7QJ7, 7QJ5, 7QJ0, 7QJ2, 6X0U, 6L81, 7QJD, 6M33, 7QJ1, 8VRJ, 7QJA, 7QJC, 8VRD, 8VRK

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZMU5 TRIM72	1	TRIM72 [cytoplasmic vesicle membrane] (R-HSA-5263653)	0.556	3