NAA translocates from mitochondrial matrix to cytosol

Stable Identifier
R-HSA-8954513
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
mitochondrial matrix, cytosol
ReviewStatus
5/5
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NAA translocates from mitochondrial matrix to cytosol
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Cytosolic acetyl-CoA (Ac-CoA) is used for lipid synthesis in adipocytes. N-acetylaspartate (NAA) is a source of Ac-CoA when catabolised in the cytosol. As no known specific NAA transporters have yet been identified, NAA translocates from the mitochondrial matrix to the cytosol by an unknown mechanism (Prokesch et al. 2016).

Literature References
PubMed ID Title Journal Year
27045997 N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes

Pospisilik, JA, Schittmayer, M, Drougard, A, Pessentheiner, AR, Birner-Gruenberger, R, Pelzmann, HJ, Bogner-Strauss, JG, Huber, K, Kolb, D, Madreiter-Sokolowski, CT, Graier, WF, Prokesch, A, Magnes, C, Trausinger, G

Sci Rep 2016
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Authored
Jassal, B  (2017-01-09)
Reviewed
D'Eustachio, P  (2017-02-06)
Created
Jassal, B  (2017-01-09)
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