Mitochondrial cardiolipin hydrolase (PLD6 aka MitoPLD) is located on the outer mitochondrial membrane and promotes trans-mitochondrial membrane adherence (mitochondrial fusion) in a Mfn-dependent manner by hydrolysing cardiolipin to generate the acidic fusogenic lipid phosphatidic acid (PA) and phosphatidylglycerol (PG) (Choi et al. 2006). Although cardiolipin is primarily an inner mitochondrial membrane-located protein, the outer mitochondrial membrane also contains around 10-20% cardiolipin and cardiolipin has been shown to translocate in a regulatable manner between the compartments (Liu et al. 2003). Mitoguardin 1 and 2 (MIGA1 and MIGA2) are regulators of mitochondrial membrane fusion. They form homo- or hetero-dimers at the mitochondrial outer membrane where they interact with PLD6 to stabilise it and/or facilitate PLD6 dimer formation (Zhang et al. 2016).
Choi, SY, Huang, P, Jenkins, GM, Chan, DC, Schiller, J, Frohman, MA
Liu, J, Dai, Q, Chen, J, Durrant, D, Freeman, A, Liu, T, Grossman, D, Lee, RM
Zhang, Y, Liu, X, Bai, J, Tian, X, Zhao, X, Liu, W, Duan, X, Shang, W, Fan, HY, Tong, C
cardiolipin hydrolase activity of PLD6 dimer [mitochondrial outer membrane]
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