Reactome | PLD6 dimer hydrolyses cardiolipin to PA and PG

PLD6 dimer hydrolyses cardiolipin to PA and PG

Stable Identifier

R-HSA-8954398

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial outer membrane, mitochondrial intermembrane space

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PLD6 dimer hydrolyses cardiolipin to PA and PG

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Mitochondrial cardiolipin hydrolase (PLD6 aka MitoPLD) is located on the outer mitochondrial membrane and promotes trans-mitochondrial membrane adherence (mitochondrial fusion) in a Mfn-dependent manner by hydrolysing cardiolipin to generate the acidic fusogenic lipid phosphatidic acid (PA) and phosphatidylglycerol (PG) (Choi et al. 2006). Although cardiolipin is primarily an inner mitochondrial membrane-located protein, the outer mitochondrial membrane also contains around 10-20% cardiolipin and cardiolipin has been shown to translocate in a regulatable manner between the compartments (Liu et al. 2003). Mitoguardin 1 and 2 (MIGA1 and MIGA2) are regulators of mitochondrial membrane fusion. They form homo- or hetero-dimers at the mitochondrial outer membrane where they interact with PLD6 to stabilise it and/or facilitate PLD6 dimer formation (Zhang et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
17028579	A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis Choi, SY, Huang, P, Jenkins, GM, Chan, DC, Schiller, J, Frohman, MA	Nat. Cell Biol.	2006
14573790	Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response Liu, J, Dai, Q, Chen, J, Durrant, D, Freeman, A, Liu, T, Grossman, D, Lee, RM	Mol. Cancer Res.	2003
26711011	Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis Zhang, Y, Liu, X, Bai, J, Tian, X, Zhao, X, Liu, W, Duan, X, Shang, W, Fan, HY, Tong, C	Mol. Cell	2016