Reactome | UCKL1 phosphorylates urindine, cytidine

UCKL1 phosphorylates urindine, cytidine

Stable Identifier

R-HSA-8954327

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Based on sequence similarity, cytosolic uridine-cytidine kinase-like 1 (UCKL1 aka F538) is thought to function as a novel human uridine kinase/uracil phosphoribosyltransferase (Kashuba et al. 2002). The two human uridine kinases 1 and 2 (UCK1 and UCK2) characterised to date phosphorylate uridine/cytidine to uridine monophosphate (UMP)/cytidine monophosphate (CMP) using ATP as a phosphate donor (Greenberg et al. 1977, Van Rompay et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
195585	Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma Webb, TE, Greenberg, N, Schumm, DE	Biochem J	1977
12199906	Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase Székely, L, Klein, G, Kashuba, V, Kashuba, E, Sandalova, T	BMC Cell Biol.	2002
11306702	Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases Linden, K, Van Rompay, AR, Norda, A, Karlsson, A, Johansson, M	Mol Pharmacol	2001