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KIRREL [plasma membrane]
Stable Identifier
R-HSA-8954311
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Kin of IRRE-like protein 1, KIRR1_HUMAN, NEPH1
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Cis-Heterodimerization of nephrin and KIRREL (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Interaction of IQGAP1 with nephrin (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin dimer:IQGAP1 [plasma membrane] (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin dimer:adherins junction-associated proteins [plasma membrane] (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin binds CASK (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin dimer:CASK [plasma membrane] (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin binds CD2AP (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin binds NCK (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin dimer:KIRREL binds FYN (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
NPHS1 dimer:KIRREL:FYN [plasma membrane] (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin interacts with Podocin (Homo sapiens)
Podocin:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Nephrin mediated activation of N-WASP (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
Phosphorylation of nephrin by FYN (Homo sapiens)
NPHS1 dimer:KIRREL:FYN [plasma membrane] (Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
PI3K:CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
KIRREL [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96J84 KIRREL
Gene Names
KIRREL, KIRREL1, NEPH1
Chain
signal peptide:1-16, chain:17-757
Reference Genes
BioGPS Gene:55243 KIRREL
COSMIC (genes):KIRREL1 KIRREL
CTD Gene:55243 KIRREL
dbSNP Gene:55243 KIRREL
ENSEMBL:ENSG00000183853 KIRREL
HGNC:15734 KIRREL
KEGG:hsa:55243 KIRREL
Monarch:55243 KIRREL
NCBI Gene:55243 KIRREL
OMIM:607428 KIRREL
UCSC:Q96J84 KIRREL
Reference Transcript
RefSeq:NM_018240.6 KIRREL
RefSeq:NM_001286349.1 KIRREL
RefSeq:XM_005245305.4 KIRREL
Other Identifiers
11736816_a_at
11736817_a_at
11750807_a_at
16672279
220825_PM_s_at
220825_s_at
225303_PM_at
225303_at
232467_PM_at
232467_at
2362090
2362091
2362121
2362122
2362124
2362125
2362126
2362127
2362128
2362129
2362130
2362131
2362132
2362134
2362136
2362138
2362139
2362140
2362141
2362142
2362143
2362145
44737_at
55243
78638_f_at
78640_r_at
7906307
A_23_P113994
A_24_P393312
A_33_P3221489
A_33_P3413821
GE778039
GE82327
GE84612
GE87531
GO:0001933
GO:0003014
GO:0003094
GO:0005515
GO:0005886
GO:0005911
GO:0007155
GO:0008092
GO:0016020
GO:0017022
GO:0030838
GO:0031253
GO:0034330
GO:0043198
GO:0045121
GO:0045217
GO:0048471
GO:0050839
GO:0097017
GO:0098609
HMNXSV003004083
HMNXSV003013298
Hs.170142.0.A1_3p_at
Hs.272234.1.S1_3p_at
ILMN_1742781
PH_hs_0029559
TC01001335.hg
g8922704_3p_a_at
Participates
as an input of
Cis-Heterodimerization of nephrin and KIRREL (Homo sapiens)
as a component of
NPHS1 dimer:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
Inferred To
ed [plasma membrane]
(Drosophila melanogaster)
KIRREL1 [plasma membrane]
(Bos taurus)
KIRREL1 [plasma membrane]
(Canis familiaris)
KIRREL1 [plasma membrane]
(Sus scrofa)
kirre [plasma membrane]
(Drosophila melanogaster)
kirrel1b [plasma membrane]
(Danio rerio)
rst [plasma membrane]
(Drosophila melanogaster)
syg-1 [plasma membrane]
(Caenorhabditis elegans)
Kirrel1 [plasma membrane]
(Mus musculus)
Kirrel1 [plasma membrane]
(Rattus norvegicus)
Homologues of KIRREL [plasma membrane]
(Drosophila melanogaster)
KIRREL [plasma membrane]
(Gallus gallus)
fred [plasma membrane]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000352138
,
ENST00000359209
OpenTargets
ENSG00000183853
HPA
ENSG00000183853-KIRREL1
PRO
Q96J84
Pharos - Targets
Q96J84
GlyGen
Q96J84
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07157 TJP1
5
TJP1 [cytosol]
(R-HSA-532659)
TJP1 [Golgi-associated vesicle membrane]
(R-HSA-3209843)
TJP1 [plasma membrane]
(R-HSA-3209845)
TJP1 (?-?) [plasma membrane]
(R-HSA-3209844)
TJP1 [cell junction]
(R-HSA-8936023)
0.672
7
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