Reactome | TPST1 [Golgi membrane]

TPST1 [Golgi membrane]

Stable Identifier

R-HSA-8954253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Protein-tyrosine sulfotransferase 1 ecNumber2.8.2.20/ecNumber, TPST1_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of hemostasis (Homo sapiens)
  - Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
    - Defective factor VIII causes hemophilia A (Homo sapiens)
      - Defective F8 sulfation at Y1699 (Homo sapiens)
        
        F8 variant is not sulfonated at Y1699 (Homo sapiens)
        
        TPST1,2 [Golgi membrane] (Homo sapiens)
        
        TPST1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60507 TPST1

Gene Names

TPST1

Chain

chain:1-370

Reference Genes

BioGPS Gene:8460 TPST1

COSMIC (genes):TPST1 TPST1

CTD Gene:8460 TPST1

dbSNP Gene:8460 TPST1

ENSEMBL:ENSG00000169902 TPST1

HGNC:12020 TPST1

KEGG:hsa:8460 TPST1

Monarch:8460 TPST1

NCBI Gene:8460 TPST1

OMIM:603125 TPST1

UCSC:O60507 TPST1

Reference Transcript

Other Identifiers

11756374_a_at

17046640

204140_PM_at

204140_at

3005451

3005452

3005453

3005454

3005465

3005466

3005467

3005468

3005476

3005498

3005503

3005507

3005508

3005509

3005510

3005511

3005544

32718_at

8133155

8460

A_14_P132057

A_23_P145965

GE54304

GO:0000139

GO:0003824

GO:0005794

GO:0006478

GO:0006790

GO:0008476

GO:0016020

GO:0016740

GO:0042803

GO:0043226

GO:0043687

GO:0050427

GO:0055086

GO:0140096

GO:1901135

HMNXSV003018926

HMNXSV003043087

ILMN_1651950

PH_hs_0019724

TC07000405.hg

g4507664_3p_at

Participates

as a member of

TPST1,2 [Golgi membrane] (Homo sapiens)

Inferred To

TPST1 [Golgi membrane] (Bos taurus)

TPST1 [Golgi membrane] (Canis familiaris)

TPST1 [Golgi membrane] (Gallus gallus)

TPST1 [Golgi membrane] (Mus musculus)

TPST1 [Golgi membrane] (Rattus norvegicus)

TPST1 [Golgi membrane] (Sus scrofa)

tpst1 [Golgi membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000497281, ENST00000649664, ENSP00000302413, ENST00000304842

OpenTargets

ENSG00000169902

HPA

ENSG00000169902-TPST1

PRO

O60507

Pharos - Targets

O60507

GlyGen

O60507

HMDB Protein

HMDBP11981

PDB

5WRI, 5WRJ

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.527	2