Reactome | TPST1 [Golgi membrane]

TPST1 [Golgi membrane]

Stable Identifier

R-HSA-8954253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Protein-tyrosine sulfotransferase 1 ecNumber2.8.2.20/ecNumber, TPST1_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of hemostasis (Homo sapiens)
  - Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
    - Defective factor VIII causes hemophilia A (Homo sapiens)
      - Defective F8 sulfation at Y1699 (Homo sapiens)
        
        F8 variant is not sulfonated at Y1699 (Homo sapiens)
        
        TPST1,2 [Golgi membrane] (Homo sapiens)
        
        TPST1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60507 TPST1

Gene Names

TPST1

Chain

chain:1-370

Reference Genes

BioGPS Gene:8460 TPST1

COSMIC (genes):TPST1 TPST1

CTD Gene:8460 TPST1

dbSNP Gene:8460 TPST1

ENSEMBL:ENSG00000169902 TPST1

HGNC:12020 TPST1

KEGG:hsa:8460 TPST1

Monarch:8460 TPST1

NCBI Gene:8460 TPST1

OMIM:603125 TPST1

UCSC:O60507 TPST1

Reference Transcript

Other Identifiers

11756374_a_at

17046640

204140_PM_at

204140_at

3005450

3005451

3005452

3005453

3005454

3005455

3005456

3005459

3005465

3005466

3005467

3005468

3005476

3005498

3005503

3005504

3005505

3005506

3005507

3005508

3005509

3005510

3005511

3005512

3005513

3005530

3005536

3005537

3005544

32718_at

8133155

8460

A_14_P132057

A_23_P145965

GE54304

GO:0000139

GO:0003824

GO:0005794

GO:0005796

GO:0005802

GO:0006478

GO:0006790

GO:0008476

GO:0016020

GO:0016740

GO:0042803

GO:0043687

GO:0050427

GO:0055086

GO:0140096

GO:1901135

HMNXSV003018926

HMNXSV003043087

ILMN_1651950

PH_hs_0019724

TC07000405.hg

g4507664_3p_at

Participates

as a member of

TPST1,2 [Golgi membrane] (Homo sapiens)

Inferred To

TPST1 [Golgi membrane] (Bos taurus)

TPST1 [Golgi membrane] (Canis familiaris)

TPST1 [Golgi membrane] (Gallus gallus)

TPST1 [Golgi membrane] (Sus scrofa)

Tpst1 [Golgi membrane] (Mus musculus)

Tpst1 [Golgi membrane] (Rattus norvegicus)

tpst1 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003587.1, XP_016868216.1, XP_054215204.1, XP_054215207.1, XP_016868215.1, XP_054215203.1, XP_054215206.1, XP_016868214.1, XP_054215205.1, XP_054215202.1, XP_047276918.1, XP_047276914.1, XP_047276915.1, XP_047276916.1

OpenTargets

ENSG00000169902

ENSEMBL

ENST00000649664, ENSP00000497281, ENSP00000302413, ENSG00000169902, ENST00000304842

HPA

ENSG00000169902-TPST1

GeneCards

TPST1

PRO

O60507

Pharos - Targets

O60507

GlyGen

O60507

PDB

5WRJ, 5WRI

HMDB Protein

HMDBP11981

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.527	2
UniProt:O60704 TPST2	1	TPST2 [Golgi membrane] (R-HSA-8954250)	0.527	3