Reactome | E2F6:TFDP1 binds EPC1

E2F6:TFDP1 binds EPC1

Stable Identifier

R-HSA-8954117

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The heterodimer of E2F6 and TFDP1 (DP-1) forms a stable tripartite complex with EPC1. EPC1 is a component of the NuA4 histone acetyltransferase complex. The complex of E2F6 and EPC1 acts as a repressive complex in a CAT reporter assay, but the presence of other NuA4 components has not been detected in co-immunoprecipitates of E2F6 and EPC1. EPC1 directly interacts with E2F6 but not with TFDP1 (Attwooll et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15536069	A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner Attwooll, C, Oddi, S, Cartwright, P, Prosperini, E, Agger, K, Steensgaard, P, Wagener, C, Sardet, C, Moroni, MC, Helin, K	J. Biol. Chem.	2005