E2F6 forms a heterodimer with TFDP2 (DP-2) (Gaubatz et al. 1998, Trimarchi et al. 1998). The E2F6:TFDP2 complex binds to the E2F binding site in the promoter of the DHFR gene, encoding Dihydrofolate reductase, in vitro (Gaubatz et al. 1998). E2F6 presumably represses DHFR transcription, but this has not been experimentally confirmed. It is not known whether other E2F6 and/or TFDP2 binding proteins are recruited to the DHFR promoter.