Reactome | E2F6 binds TFDP2

E2F6 binds TFDP2

Stable Identifier

R-HSA-8954056

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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E2F6 forms a heterodimer with TFDP2 (DP-2) (Gaubatz et al. 1998, Trimarchi et al. 1998). The E2F6:TFDP2 complex binds to the E2F binding site in the promoter of the DHFR gene, encoding Dihydrofolate reductase, in vitro (Gaubatz et al. 1998). E2F6 presumably represses DHFR transcription, but this has not been experimentally confirmed. It is not known whether other E2F6 and/or TFDP2 binding proteins are recruited to the DHFR promoter.

Literature References

PubMed ID	Title	Journal	Year
9689056	Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6 Gaubatz, S, Wood, JG, Livingston, DM	Proc. Natl. Acad. Sci. U.S.A.	1998
9501179	E2F-6, a member of the E2F family that can behave as a transcriptional repressor Trimarchi, JM, Fairchild, B, Verona, R, Moberg, K, Andon, N, Lees, JA	Proc. Natl. Acad. Sci. U.S.A.	1998