Reactome | Ub-C11-PEX5S [peroxisomal membrane]

Ub-C11-PEX5S [peroxisomal membrane]

Stable Identifier

R-HSA-8953944

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

Peroxisomal targeting signal 1 receptor, PEX5_HUMAN

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
      - PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
        
        PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
        
        Ub:PEX5S,L [peroxisomal membrane] (Homo sapiens)
        
        Ub:PEX5S [peroxisomal membrane] (Homo sapiens)
        
        Ub-C11-PEX5S [peroxisomal membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50542-2 PEX5

Gene Names

PEX5, PXR1

Participates

as a component of

Ub:PEX5S [peroxisomal membrane] (Homo sapiens)

Other forms of this molecule

Ub-C11-PEX5S [cytosol]

PEX5 isoform S [cytosol]

PEX5 isoform S [peroxisomal membrane]

Inferred To

pex5 [peroxisomal membrane] (Dictyostelium discoideum)

pex5 [peroxisomal membrane] (Schizosaccharomyces pombe)

pex5 [peroxisomal membrane] (Xenopus tropicalis)

Ub-C11-PEX5L [peroxisomal membrane] (Gallus gallus)

Pex5 [peroxisomal membrane] (Drosophila melanogaster)

Pex5 [peroxisomal membrane] (Mus musculus)

Pex5 [peroxisomal membrane] (Rattus norvegicus)

prx-5 [peroxisomal membrane] (Caenorhabditis elegans)

PEX5 [peroxisomal membrane] (Bos taurus)

PEX5 [peroxisomal membrane] (Canis familiaris)

PEX5 [peroxisomal membrane] (Saccharomyces cerevisiae)

PEX5 [peroxisomal membrane] (Sus scrofa)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 11

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75381 PEX14	2	PEX14 [cytosol] (R-HSA-9603806) PEX14 [peroxisomal membrane] (R-HSA-9033101)	0.807	13
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.683	4
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.556	3
UniProt:EP400NL H9KV84			0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q49A88 CCD14			0.556	3
UniProt:Q6NSB6 Q6NSB6			0.556	3
UniProt:A8K3Q9 A8K3Q9			0.556	3
UniProt:Q8N5N8 Q8N5N8			0.556	3
UniProt:Q75MR5 Q75MR5			0.556	3
UniProt:Q6IPH7 Q6IPH7			0.556	3
UniProt:Q68DY9 ZNF772	1	ZNF772 [nucleoplasm] (R-HSA-3110231)	0.556	3
UniProt:P06703 S10A6			0.556	3
UniProt:Q6IMN6 CAPR2			0.556	3
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.556	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.556	3
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2