Reactome | PDHA2 [mitochondrial matrix]

PDHA2 [mitochondrial matrix]

Stable Identifier

R-HSA-8953513

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial ecNumber1.2.4.1/ecNumber, ODPAT_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - Signaling by Retinoic Acid (Homo sapiens)
    - PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
      - PDH complex [mitochondrial matrix] (Homo sapiens)
        
        PDH E1 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1,2 [mitochondrial matrix] (Homo sapiens)
        
        PDHA2 [mitochondrial matrix] (Homo sapiens)
      - p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
        
        PDH E1 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1,2 [mitochondrial matrix] (Homo sapiens)
        
        PDHA2 [mitochondrial matrix] (Homo sapiens)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Homo sapiens)
        
        PDH E1 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1,2 [mitochondrial matrix] (Homo sapiens)
        
        PDHA2 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29803 PDHA2

Gene Names

PDHA2, PDHAL

Chain

transit peptide:1-27, chain:28-388

Reference Genes

BioGPS Gene:5161 PDHA2

COSMIC (genes):PDHA2 PDHA2

CTD Gene:5161 PDHA2

dbSNP Gene:5161 PDHA2

ENSEMBL:ENSG00000163114 PDHA2

HGNC:8807 PDHA2

KEGG:hsa:5161 PDHA2

Monarch:5161 PDHA2

NCBI Gene:5161 PDHA2

OMIM:179061 PDHA2

UCSC:P29803 PDHA2

Reference Transcript

RefSeq:NM_005390.4 PDHA2

Other Identifiers

11734083_at

16969070

214518_PM_at

214518_at

2736654

2736655

2736656

2736657

33013_at

5161

8096528

ADDON002878.hg

A_14_P139780

A_14_P201083

A_14_P202299

A_23_P81018

GE58120

GO:0003824

GO:0004739

GO:0005515

GO:0005634

GO:0005730

GO:0005739

GO:0005759

GO:0005975

GO:0006006

GO:0006086

GO:0006090

GO:0006099

GO:0006790

GO:0016491

GO:0016624

GO:0034604

GO:0043226

GO:0043231

GO:0045254

GO:0055086

GO:1901135

HMNXSV003049995

Hs.131361.0.S1_3p_at

ILMN_1665458

ILMN_2068951

M86808_at

PH_hs_0007788

TC04000504.hg

Participates

as a member of

PDHA1,2 [mitochondrial matrix] (Homo sapiens)

Inferred To

PDHA2 [mitochondrial matrix] (Bos taurus)

PDHA2 [mitochondrial matrix] (Caenorhabditis elegans)

PDHA2 [mitochondrial matrix] (Dictyostelium discoideum)

PDHA2 [mitochondrial matrix] (Gallus gallus)

PDHA2 [mitochondrial matrix] (Mus musculus)

PDHA2 [mitochondrial matrix] (Rattus norvegicus)

PDHA2 [mitochondrial matrix] (Saccharomyces cerevisiae)

PDHA2 [mitochondrial matrix] (Schizosaccharomyces pombe)

Homologues of PDHA2 [mitochondrial matrix] (Bos taurus)

Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)

Homologues of PDHA2 [mitochondrial matrix] (Mus musculus)

Homologues of PDHA2 [mitochondrial matrix] (Rattus norvegicus)

Pdha [mitochondrial matrix] (Drosophila melanogaster)

Dmel\CG7024 [mitochondrial matrix] (Drosophila melanogaster)

PDHA1 [mitochondrial matrix] (Bos taurus)

PDHA1 [mitochondrial matrix] (Canis familiaris)

PDHA1 [mitochondrial matrix] (Sus scrofa)

Pdha1l1 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_005381.1

ENSEMBL

ENST00000295266, ENSP00000295266

OpenTargets

ENSG00000163114

HPA

ENSG00000163114-PDHA2

PRO

P29803

Pharos - Targets

P29803

HMDB Protein

HMDBP00050