SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex

Stable Identifier
R-HSA-8953461
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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During or after processing of the transit peptide of proSMDT1 (proEMRE), the mature SMDT1 is incorporated with MCU, MCUB, MICU1, and MICU2 (or MICU3 in neurons) into the mitochondrial calcium uniporter (MCU) complex (Konig et al. 2016). MCUR1 may also be a member of the MCU complex, however this is controversial.

Literature References
PubMed ID Title Journal Year
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

König, T, Tröder, SE, Bakka, K, Korwitz, A, Richter-Dennerlein, R, Lampe, PA, Patron, M, Mühlmeister, M, Guerrero-Castillo, S, Brandt, U, Decker, T, Lauria, I, Paggio, A, Rizzuto, R, Rugarli, EI, De Stefani, D, Langer, T

Mol. Cell 2016
Participants
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Orthologous Events
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