PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix

Stable Identifier
R-HSA-8953430
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxisomal membrane protein 2 (PXMP2) homotrimer is inferred from the properties of its mouse homolog to form a channel in the peroxisomal membrane that allows the passage of glycolate and other molecules with molecular masses less than 200 Da between the cytosol and the peroxisomal matrix (Rokka et al. 2009; Wanders et al. 2016).

Literature References
PubMed ID Title Journal Year
19352492 Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane

Rokka, A, Antonenkov, VD, Soininen, R, Immonen, HL, Pirilä, PL, Bergmann, U, Sormunen, RT, Weckström, M, Benz, R, Hiltunen, JK

PLoS ONE 2009
26858947 Metabolic Interplay between Peroxisomes and Other Subcellular Organelles Including Mitochondria and the Endoplasmic Reticulum

Wanders, RJ, Waterham, HR, Ferdinandusse, S

Front Cell Dev Biol 2015
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
channel activity of PXMP2 trimer [peroxisomal membrane]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Reviewed
Created