Reactome | PIR oxygenates quercetin

PIR oxygenates quercetin

Stable Identifier

R-HSA-8953398

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Quercetin is an abundant flavonoid found in edible vegetables, grains and fruits and is used as an ingredient in supplements, beverages, or foods. Pirin (PIR) is a highly conserved nuclear protein (Wendler et al. 1997) which possesses quercetinase activity, transforming quercetin to 2-protocatechuoylphloroglucinol carboxylic acid (2PCPGCA) and carbon monoxide (CO) (Adams & Jia 2005). Quercetin supplements have been promoted for the treatment of a wide spectrum of diseases including cancer but there is insufficient evidence to draw any conclusive proof of its beneficial effects to date (Miles et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
15951572	Structural and biochemical analysis reveal pirins to possess quercetinase activity Adams, M, Jia, Z	J. Biol. Chem.	2005
9079676	Identification of pirin, a novel highly conserved nuclear protein Wendler, WM, Kremmer, E, Förster, R, Winnacker, EL	J. Biol. Chem.	1997