PIR oxygenates quercetin

Stable Identifier
R-HSA-8953398
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Quercetin is an abundant flavonoid found in edible vegetables, grains and fruits and is used as an ingredient in supplements, beverages, or foods. Pirin (PIR) is a highly conserved nuclear protein (Wendler et al. 1997) which possesses quercetinase activity, transforming quercetin to 2-protocatechuoylphloroglucinol carboxylic acid (2PCPGCA) and carbon monoxide (CO) (Adams & Jia 2005). Quercetin supplements have been promoted for the treatment of a wide spectrum of diseases including cancer but there is insufficient evidence to draw any conclusive proof of its beneficial effects to date (Miles et al. 2014).

Literature References
PubMed ID Title Journal Year
9079676 Identification of pirin, a novel highly conserved nuclear protein

Wendler, WM, Kremmer, E, Förster, R, Winnacker, EL

J. Biol. Chem. 1997
15951572 Structural and biochemical analysis reveal pirins to possess quercetinase activity

Adams, M, Jia, Z

J. Biol. Chem. 2005
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
quercetin 2,3-dioxygenase activity of PIR [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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