Reactome | E2F8 forms homodimers

E2F8 forms homodimers

Stable Identifier

R-HSA-8953037

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        E2F8 forms homodimers (Homo sapiens)

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E2F8 forms homodimers (Maiti et al. 2005, Li et al. 2008). E2F8 also forms heterodimers with E2F7 and co-immunoprecipitation experiments suggest that E2F8 has higher affinity for E2F7 than for itself (Zalmas et al. 2008, Li et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
15722552	Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation Li, J, Maiti, B, Tuttle, J, Patil, K, Gordon, F, Cleghorn, W, Leone, G, Timmers, C, de Bruin, A, Opavsky, R	J. Biol. Chem.	2005
18202719	DNA-damage response control of E2F7 and E2F8 Coutts, AS, Reilly, C, Zalmas, LP, La Thangue, NB, Zhao, X, Fisher, R, Graham, AL	EMBO Rep.	2008
18194653	Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development Siddiqui, H, Ran, C, Li, J, de Bruin, A, Chen, HZ, Li, E, Kornacker, K, Pandit, SK, Khanizadeh, M, Liu, CG, Gordon, F, Cleghorn, W, Leone, G, Comstock, G, Weinstein, M	Dev. Cell	2008