Reactome | E2F7 binds E2F8

E2F7 binds E2F8

Stable Identifier

R-HSA-8953013

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        E2F7 binds E2F8 (Homo sapiens)

General

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E2F7 forms heterodimers with E2F8 (Li et al. 2008, Zalmas et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18202719	DNA-damage response control of E2F7 and E2F8 Coutts, AS, Reilly, C, Zalmas, LP, La Thangue, NB, Zhao, X, Fisher, R, Graham, AL	EMBO Rep.	2008
18194653	Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development Siddiqui, H, Ran, C, Li, J, de Bruin, A, Chen, HZ, Li, E, Kornacker, K, Pandit, SK, Khanizadeh, M, Liu, CG, Gordon, F, Cleghorn, W, Leone, G, Comstock, G, Weinstein, M	Dev. Cell	2008