ADPRHL2 hydrolyses poly(ADP-ribose)

Stable Identifier
R-HSA-8952903
Type
Reaction [transition]
Species
Homo sapiens
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Important cellular processes such as DNA repair, cellular differentiation, and carcinogenesis are regulated by poly(ADP-ribosyl)ation. Previously, only the nuclear protein poly(ADP-ribose) glycohydrolase (PARG) has been identified to hydrolyse poly(ADP-ribose). Poly(ADP-ribose) glycohydrolase ARH3 (ADPRHL2) is a mitochondrial matrix protein (Niere et al. 2008) structurally unrelated to PARG but possessing PARG activity (Oka et al. 2006). ADPRHL2 is able to hydrolyse poly(ADP-ribose) in mitochondria (Niere et al. 2012).

Literature References
PubMed ID Title Journal Year
17991898 Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix

Niere, M, Kernstock, S, Koch-Nolte, F, Ziegler, M

Mol. Cell. Biol. 2008
16278211 Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase

Oka, S, Kato, J, Moss, J

J. Biol. Chem. 2006
22433848 ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose)

Niere, M, Mashimo, M, Agledal, L, Dölle, C, Kasamatsu, A, Kato, J, Moss, J, Ziegler, M

J. Biol. Chem. 2012
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Catalyst Activity
Title
poly(ADP-ribose) glycohydrolase activity of ADPRHL2 [mitochondrial matrix]
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Orthologous Events
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