Reactome | ADPRHL2 hydrolyses poly(ADP-ribose)

ADPRHL2 hydrolyses poly(ADP-ribose)

Stable Identifier

R-HSA-8952903

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Important cellular processes such as DNA repair, cellular differentiation, and carcinogenesis are regulated by poly(ADP-ribosyl)ation. Previously, only the nuclear protein poly(ADP-ribose) glycohydrolase (PARG) has been identified to hydrolyse poly(ADP-ribose). Poly(ADP-ribose) glycohydrolase ARH3 (ADPRHL2) is a mitochondrial matrix protein (Niere et al. 2008) structurally unrelated to PARG but possessing PARG activity (Oka et al. 2006). ADPRHL2 is able to hydrolyse poly(ADP-ribose) in mitochondria (Niere et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
16278211	Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase Moss, J, Kato, J, Oka, S	J. Biol. Chem.	2006
17991898	Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix Ziegler, M, Koch-Nolte, F, Kernstock, S, Niere, M	Mol. Cell. Biol.	2008
22433848	ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose) Mashimo, M, Ziegler, M, Agledal, L, Dölle, C, Moss, J, Kato, J, Kasamatsu, A, Niere, M	J. Biol. Chem.	2012