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p-Y693-STAT4 dissociates after IL12:IL12R interaction
Stable Identifier
R-HSA-8952807
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated Signal transducer and activator of transcription 4 (STAT4) dissociates from the receptor, dimerizes, translocates to the nucleus and binds to STAT target sequences in Interleukin-12 responsive genes (Cho et al.1996, Bacon et al. 1995).
This is a Black Box Event since the exact mechanism of association and dissociation of STATs is not described.
Literature References
PubMed ID
Title
Journal
Year
15087447
Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells
Pober, JS
,
Torpey, N
,
Maher, SE
,
Bothwell, AL
J. Biol. Chem.
2004
Participants
Input
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane]
(Homo sapiens)
Output
x 2
p-Y693-STAT4 [cytosol]
(Homo sapiens)
Participates
as an event of
Interleukin-12 signaling (Homo sapiens)
Orthologous Events
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Bos taurus)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Mus musculus)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Sus scrofa)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Xenopus tropicalis)
Authored
Duenas, C (2016-12-02)
Reviewed
van de Vosse, E (2017-05-12)
Created
Duenas, C (2016-12-16)
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