SLC38A9 binds Ragulator:Rag dimers

Stable Identifier
Reaction [binding]
Homo sapiens
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The sodium-coupled neutral amino acid transporter 9 (SLC38A9 aka URLC11) is a lysosomal membrane protein mediating the transport of amino acids. It is proposed SLC38A9 acts as an amino acid sensor of the Ragulator and Rag GTPases complexes which are involved in the activation of mTORC1. The serine/threonine kinase mTORC1 regulates cellular homeostasis in response to many stimuli, such as nutrient status (for example via the transport of amino acids by SLC38A9) and energy level. SLC38A9 has been established to be an integral part of the Ragulator:Rag GTPase complex (Rebsamen et al. 2015, Wang et al. 2015, Jung et al. 2015).

Literature References
PubMed ID Title Journal Year
25567906 Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Sabatini, DM, Wang, T, Zoncu, R, Jones, TD, Comb, W, Park, J, Straub, C, Wang, S, Shen, K, Tsun, ZY, Bar-Peled, L, Plovanich, ME, Chantranupong, L, Sabatini, BL, Kim, C, Yuan, ED, Wyant, GA, Wolfson, RL

Science 2015
25561175 SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Bigenzahn, JW, Huber, KV, Indiveri, C, Bennett, KL, Rebsamen, M, Superti-Furga, G, Kandasamy, RK, Rudashevskaya, EL, Snijder, B, Galluccio, M, Huber, LA, Heinz, LX, de Ara├║jo, ME, Pochini, L, Fauster, A, Filipek, PA, Bruckner, M, Scorzoni, S, Kraft, C, Stasyk, T

Nature 2015
25963655 Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

Behrends, C, Jung, J, Genau, HM

Mol. Cell. Biol. 2015
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