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NKIRAS1 [cytosol]
Stable Identifier
R-HSA-8952686
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NF-kappa-B inhibitor-interacting Ras-like protein 1, KBRS1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYS0 NKIRAS1
Gene Names
NKIRAS1, KBRAS1
Chain
chain:1-192
Reference Genes
BioGPS Gene:28512 NKIRAS1
COSMIC (genes):NKIRAS1 NKIRAS1
CTD Gene:28512 NKIRAS1
dbSNP Gene:28512 NKIRAS1
ENSEMBL:ENSG00000197885.11 NKIRAS1
HGNC:17899 NKIRAS1
KEGG Gene (Homo sapiens):28512 NKIRAS1
Monarch:28512 NKIRAS1
NCBI Gene:28512 NKIRAS1
OMIM:604496 NKIRAS1
UCSC:Q9NYS0 NKIRAS1
Reference Transcript
RefSeq:XM_005265078.3 NKIRAS1
RefSeq:XM_005265076.3 NKIRAS1
RefSeq:XM_005265077.4 NKIRAS1
RefSeq:NM_020345.3 NKIRAS1
Other Identifiers
0002650398
11723997_a_at
16951548
225930_PM_at
225930_at
238958_PM_at
238958_at
2666099
2666101
2666102
2666104
2666105
2666106
2666107
2666109
2666110
2666111
2666112
2666113
2666114
2666115
2666121
28512
54816_at
65298_at
8085788
A_23_P338519
GE79636
GO:0000166
GO:0003924
GO:0005525
GO:0005622
GO:0005737
GO:0005783
GO:0005829
GO:0007249
GO:0010803
GO:0016787
GO:0023052
GO:0032484
GO:0032794
GO:0043129
GO:0043226
GO:0048286
GO:0048856
HMNXSV003055862
Hs.163546.0.A1_3p_at
Hs.163546.0.A1_3p_x_at
Hs.173202.0.S2_3p_at
ILMN_1664216
PH_hs_0031998
TC03001239.hg
Participates
as a member of
NKIRAS [cytosol] (Homo sapiens)
Inferred To
Nkiras1 [cytosol]
(Rattus norvegicus)
NKIRAS1 [cytosol]
(Bos taurus)
NKIRAS1 [cytosol]
(Canis familiaris)
NKIRAS1 [cytosol]
(Danio rerio)
NKIRAS1 [cytosol]
(Drosophila melanogaster)
NKIRAS1 [cytosol]
(Mus musculus)
NKIRAS1 [cytosol]
(Sus scrofa)
nkiras1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_065078.1
,
XP_005265134.1
,
XP_005265133.1
,
XP_005265135.1
OpenTargets
ENSG00000197885
HPA
ENSG00000197885-NKIRAS1
GeneCards
Q9NYS0
Ensembl
ENSP00000483749
,
ENSP00000373411
,
ENST00000416026
,
ENST00000421515
,
ENSP00000400385
,
ENST00000425478
,
ENST00000443659
,
ENSP00000394214
,
ENSP00000393785
,
ENSG00000197885
,
ENST00000388759
,
ENSP00000392307
,
ENST00000614374
PRO
Q9NYS0
Pharos - Targets
Q9NYS0
HMDB Protein
HMDBP08473
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