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NKIRAS2 [cytosol]
Stable Identifier
R-HSA-8952684
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NF-kappa-B inhibitor-interacting Ras-like protein 2, KBRS2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Homo sapiens)
NKIRAS [cytosol] (Homo sapiens)
NKIRAS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYR9 NKIRAS2
Gene Names
NKIRAS2, KBRAS2
Chain
chain:1-191
Reference Genes
BioGPS Gene:28511 NKIRAS2
COSMIC (genes):NKIRAS2 NKIRAS2
CTD Gene:28511 NKIRAS2
dbSNP Gene:28511 NKIRAS2
ENSEMBL:ENSG00000168256 NKIRAS2
HGNC:17898 NKIRAS2
KEGG:hsa:28511 NKIRAS2
Monarch:28511 NKIRAS2
NCBI Gene:28511 NKIRAS2
OMIM:604497 NKIRAS2
UCSC:Q9NYR9 NKIRAS2
Reference Transcript
RefSeq:XM_005257251.1 NKIRAS2
RefSeq:NM_001144927.1 NKIRAS2
RefSeq:NM_001144929.1 NKIRAS2
RefSeq:NM_001144928.1 NKIRAS2
RefSeq:NM_001001349.2 NKIRAS2
RefSeq:NM_017595.5 NKIRAS2
Other Identifiers
11723631_a_at
11726270_x_at
11741189_x_at
11754089_x_at
16834252
218240_PM_at
218240_at
222105_PM_s_at
222105_s_at
28511
3721580
3721585
3721586
3721587
3721588
3721589
3721590
3721591
3721592
3721593
3721594
3721595
3721596
3721597
3721598
3721599
3721600
56329_at
8007197
90254_at
A_14_P108749
A_14_P113313
A_14_P113361
A_23_P10135
A_24_P152335
A_33_P3380331
GE56779
GE87446
GO:0000166
GO:0003824
GO:0003924
GO:0005525
GO:0005575
GO:0005737
GO:0006954
GO:0010803
GO:0016787
GO:0032484
GO:0032794
GO:0043122
GO:0043124
GO:0043129
GO:0048286
GO:0048856
HMNXSV003001060
Hs.22937.1.S2_3p_a_at
ILMN_1653404
ILMN_1677481
ILMN_1699778
PH_hs_0026552
TC17000521.hg
Participates
as a member of
NKIRAS [cytosol] (Homo sapiens)
Inferred To
Nkiras2 [cytosol]
(Rattus norvegicus)
NKIRAS2 [cytosol]
(Bos taurus)
NKIRAS2 [cytosol]
(Canis familiaris)
NKIRAS2 [cytosol]
(Drosophila melanogaster)
NKIRAS2 [cytosol]
(Mus musculus)
NKIRAS2 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000377458
,
ENSP00000377459
,
ENSP00000465633
,
ENST00000307641
,
ENST00000393885
,
ENSP00000303580
,
ENST00000393880
,
ENST00000449471
,
ENST00000393881
,
ENSP00000401976
,
ENST00000479407
,
ENSG00000168256
,
ENSP00000377463
OpenTargets
ENSG00000168256
GeneCards
NKIRAS2
HPA
ENSG00000168256-NKIRAS2
PRO
Q9NYR9
Pharos - Targets
Q9NYR9
HMDB Protein
HMDBP08474
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