Reactome | AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex

AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex

Stable Identifier

R-HSA-8952631

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

UBE2M transfers NEDD8 to lysine 712 of CUL3 in the E3 ligase complex (Hori et al, 1999; Duda et al, 2008). Neddylation increases the ubiquitin ligase activity of the E3 complex towards its targets, and prevents binding of the CUL3 complex with the CAND1 inhibitor (Hori et al, 1999; Duda et al, 2008). CRL3 ubiquitin ligase complexes target substrates through a BTB substrate recognition protein, and regulate processes such as development and stress response, as well as viral replication (reviewed in Genschik et al, 2013; Mahon et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
25314029	Cullin E3 ligases and their rewiring by viral factors Pick, E, Mahon, C, Krogan, NJ, Craik, CS	Biomolecules	2014
10597293	Covalent modification of all members of human cullin family proteins by NEDD8 Kato, S, Shimbara, N, Miyamoto, C, Osaka, F, Okabayashi, K, Chiba, T, Tanaka, K, Hori, T	Oncogene	1999
23912815	The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications Lechner, E, Sumara, I, Genschik, P	EMBO J.	2013
18805092	Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation Borg, LA, Hunt, HW, Duda, DM, Schulman, BA, Hammel, M, Scott, DC	Cell	2008