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NEDD8-CRL4 E3 ligase complex [nucleoplasm]
Stable Identifier
R-HSA-8952584
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19481520
The CUL4 enigma: culling DNA repair factors
Sugasawa, K
Mol Cell
2009
17588513
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
Lee, J
,
Zhou, P
Mol Cell
2007
Participants
components
DCAF protein [nucleoplasm]
(Homo sapiens)
DDB1 [nucleoplasm]
(Homo sapiens)
NEDD8:CUL4 [nucleoplasm]
(Homo sapiens)
RBX1 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
Inferred To
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Bos taurus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Caenorhabditis elegans)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Canis familiaris)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Danio rerio)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Dictyostelium discoideum)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Drosophila melanogaster)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Gallus gallus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Mus musculus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Rattus norvegicus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Sus scrofa)
NEDD8-CRL4 E3 ligase complex [nucleoplasm]
(Xenopus tropicalis)
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