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G76-NEDD8-K705-CUL4A [nucleoplasm]
Stable Identifier
R-HSA-8952514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-4A, CUL4A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
NEDD8:CUL4 [nucleoplasm] (Homo sapiens)
G76-NEDD8-K705-CUL4A [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
NEDD8:CUL4 [nucleoplasm] (Homo sapiens)
G76-NEDD8-K705-CUL4A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13619 CUL4A
Gene Names
CUL4A
Chain
chain:1-759
Reference Genes
BioGPS Gene:8451 CUL4A
COSMIC (genes):CUL4A CUL4A
CTD Gene:8451 CUL4A
dbSNP Gene:8451 CUL4A
ENSEMBL:ENSG00000139842 CUL4A
ENSEMBL_homo_sapiens_GENE:ENSG00000139842.15 CUL4A
HGNC:2554 CUL4A
KEGG Gene (Homo sapiens):8451 CUL4A
Monarch:8451 CUL4A
NCBI Gene:8451 CUL4A
OMIM:603137 CUL4A
UCSC:Q13619 CUL4A
Reference Transcript
RefSeq:NM_001278513.1 CUL4A
RefSeq:NM_003589.2 CUL4A
RefSeq:XM_011537523.2 CUL4A
RefSeq:NM_001008895.2 CUL4A
Other Identifiers
11743766_a_at
11748671_a_at
11752001_a_at
16776827
201423_PM_s_at
201423_s_at
201424_PM_s_at
201424_s_at
3502499
3502500
3502501
3502503
3502504
3502506
3502507
3502510
3502511
3502512
3502515
3502517
3502521
3502523
3502527
3502534
3502537
3502538
3502543
3502545
3502546
3502547
3502549
3502550
3502552
3502557
3502558
3502559
3502560
3502561
3502563
3502564
40908_r_at
7970262
8451
A_23_P151471
A_24_P61467
A_33_P3322909
GE873867
GO:0000082
GO:0000278
GO:0001701
GO:0002376
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006281
GO:0006511
GO:0006974
GO:0007283
GO:0008283
GO:0008284
GO:0012501
GO:0016567
GO:0016740
GO:0022414
GO:0023052
GO:0030097
GO:0030154
GO:0030163
GO:0030853
GO:0031461
GO:0031464
GO:0031625
GO:0034644
GO:0035019
GO:0036211
GO:0042110
GO:0042254
GO:0043161
GO:0043226
GO:0045732
GO:0048511
GO:0048856
GO:0051246
GO:0061630
GO:0080008
GO:0097193
GO:0140096
GO:0140627
GO:0160072
GO:1900087
GO:2000001
GO:2000819
HMNXSV003006474
Hs.183874.0.A1_3p_a_at
ILMN_1686156
ILMN_1695792
ILMN_2331163
PH_hs_0023344
TC13000419.hg
U58090_at
g11140810_3p_a_at
Participates
as a member of
NEDD8:CUL4 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CUL4A [nucleoplasm]
Inferred To
cul-4 [nucleoplasm]
(Caenorhabditis elegans)
zgc:64071 [nucleoplasm]
(Danio rerio)
CUL4A [nucleoplasm]
(Bos taurus)
CUL4A [nucleoplasm]
(Canis familiaris)
CUL4A [nucleoplasm]
(Sus scrofa)
cul4a [nucleoplasm]
(Xenopus tropicalis)
culD [nucleoplasm]
(Dictyostelium discoideum)
Cul4 [nucleoplasm]
(Drosophila melanogaster)
Cul4a [nucleoplasm]
(Mus musculus)
Cul4a [nucleoplasm]
(Rattus norvegicus)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(Gallus gallus)
Modified Residues
Name
neddylated lysine (monoNEDD8 [nucleoplasm]) at 705
Coordinate
705
Modification
monoNEDD8 [nucleoplasm]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
NP_003580.1
,
NP_001008895.1
,
NP_001265442.1
,
XP_011535825.1
OpenTargets
ENSG00000139842
GeneCards
Q13619
HPA
ENSG00000139842-CUL4A
Ensembl
ENST00000451881
,
ENST00000375440
,
ENST00000375441
,
ENSP00000481782
,
ENSP00000364589
,
ENSP00000389118
,
ENSG00000139842
,
ENSP00000364590
,
ENST00000617546
PRO
Q13619
Pharos - Targets
Q13619
Orphanet
25733
PDB
7OKQ
,
7OPD
,
4A0K
,
2HYE
,
7OPC
,
8B3I
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92466 DDB2
3
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
0.848
10
UniProt:Q86VP6 CAND1
5
CAND1 [cytosol]
(R-HSA-5691146)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [nucleoplasm]
(R-HSA-8955089)
0.723
6
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.623
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:Q96SW2 CRBN
1
CRBN [cytosol]
(R-HSA-8863300)
0.528
5
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.527
2
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
8
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.527
3
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [cytosol]
(R-HSA-1181251)
0.499
2
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