Polyubiquitinated RUNX3 is degraded by the proteasome

Stable Identifier
R-HSA-8952408
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Polyubiquitinated RUNX3 is degraded by the proteasome
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Polyubiquitinated RUNX3 is degraded by the proteasome (Chi et al. 2009).
Literature References
PubMed ID Title Journal Year
19808967 Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

Lee, KS, Lee, YH, Lee, JW, Bae, SC, Kim, J, Park, WY, van Wijnen, AJ, Ito, Y, Chi, XZ, Oh, BC, Wee, H, Stein, GS, Kim, WJ

Cancer Res. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)
Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)
Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
Polyubiquitinated RUNX3 is degraded by the proteasome (Gallus gallus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-15)
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