MDM2 polyubiquitinates RUNX3

Stable Identifier
R-HSA-8952382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MDM2 polyubiquitinates RUNX3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MDM2 polyubiquitinates RUNX3 on lysine residues K94 and K148. MDM-mediated ubiquitination of RUNX3 is inhibited by p14-ARF (Chi et al. 2009).
Literature References
PubMed ID Title Journal Year
19808967 Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

Chi, XZ, Kim, J, Lee, YH, Lee, JW, Lee, KS, Wee, H, Kim, WJ, Park, WY, Oh, BC, Stein, GS, Ito, Y, van Wijnen, AJ, Bae, SC

Cancer Res. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]

Physical Entity
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
This event is regulated
Negatively by
Regulator
p14ARF [nucleoplasm] (Homo sapiens)
Orthologous Events
MDM2 polyubiquitinates RUNX3 (Bos taurus)
MDM2 polyubiquitinates RUNX3 (Canis familiaris)
MDM2 polyubiquitinates RUNX3 (Danio rerio)
MDM2 polyubiquitinates RUNX3 (Gallus gallus)
MDM2 polyubiquitinates RUNX3 (Mus musculus)
MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)
MDM2 polyubiquitinates RUNX3 (Sus scrofa)
MDM2 polyubiquitinates RUNX3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-14)
Cite Us!