MDM2 polyubiquitinates RUNX3 on lysine residues K94 and K148. MDM-mediated ubiquitination of RUNX3 is inhibited by p14-ARF (Chi et al. 2009).
van Wijnen, AJ,
ubiquitin protein ligase activity of RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]