PLA2G15 hydrolyses LPC to GPCho and LCFA(-)

Stable Identifier
R-HSA-8952251
Type
Reaction
Species
Homo sapiens
Compartment
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Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the esterification of plasma cholesterol. Group XV phospholipase A2 (PLA2G15 aka LCAT-like lysophospholipase, LLPL or lysosomal phospholipase A2, LPLA2) bears 49% sequence similarity to LCAT (Taniyama et al. 1999) and is present in plasma. PLA2G15 possesses both calcium-independent phospholipase A(2) and transacylase activities (Abe & Shayman 1998) and could hydrolyse lysophosphatidylcholine (lysoPC), a proatherogenic lipid, to glycerophosphorylcholine (GPCho) and a free fatty acid anion (LCFA(-)) (Taniyama et al. 1999, Hiraoka et al. 2002).

Literature References
PubMed ID Title Journal Year
10092508 Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase

Fuse, H, Shirafuji, H, Taniyama, Y, Sumino, Y, Kita, S, Horikoshi, K, Fujino, M, Shibata, S

Biochem. Biophys. Res. Commun. 1999
9525960 Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity

Shayman, JA, Abe, A

J. Biol. Chem. 1998
11790796 Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase

Shayman, JA, Hiraoka, M, Abe, A

J. Biol. Chem. 2002
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Catalyst Activity

calcium-independent phospholipase A2 activity of PLA2G15 [extracellular region]

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