Reactome | PLA2G15 hydrolyses LPC to GPCho and LCFA(-)

PLA2G15 hydrolyses LPC to GPCho and LCFA(-)

Stable Identifier

R-HSA-8952251

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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PLA2G15 hydrolyses LPC to GPCho and LCFA(-)

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Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the esterification of plasma cholesterol. Group XV phospholipase A2 (PLA2G15 aka LCAT-like lysophospholipase, LLPL or lysosomal phospholipase A2, LPLA2) bears 49% sequence similarity to LCAT (Taniyama et al. 1999) and is present in plasma. PLA2G15 possesses both calcium-independent phospholipase A(2) and transacylase activities (Abe & Shayman 1998) and could hydrolyse lysophosphatidylcholine (lysoPC), a proatherogenic lipid, to glycerophosphorylcholine (GPCho) and a free fatty acid anion (LCFA(-)) (Taniyama et al. 1999, Hiraoka et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
10092508	Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase Taniyama, Y, Shibata, S, Kita, S, Horikoshi, K, Fuse, H, Shirafuji, H, Sumino, Y, Fujino, M	Biochem. Biophys. Res. Commun.	1999
9525960	Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity Abe, A, Shayman, JA	J. Biol. Chem.	1998
11790796	Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase Hiraoka, M, Abe, A, Shayman, JA	J. Biol. Chem.	2002