RUNX3 binds TP53

Stable Identifier
R-HSA-8952128
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RUNX3 can bind to TP53 (p53). The interaction involves the C-termini of both RUNX3 and TP53. RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21). RUNX3 may also interact with phosphorylated ATM kinase in response to DNA damage and facilitate ATM-mediated phosphorylation and stabilization of TP53 (Yamada et al. 2010).

Literature References
PubMed ID Title Journal Year
20353948 RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53

Yamada, C, Ozaki, T, Ando, K, Suenaga, Y, Inoue, K, Ito, Y, Okoshi, R, Kageyama, H, Kimura, H, Miyazaki, M, Nakagawara, A

J. Biol. Chem. 2010
Participants
Participant Of
Orthologous Events
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Created