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BRD2 [nucleoplasm]
Stable Identifier
R-HSA-8951979
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Bromodomain-containing protein 2, RING3, Really interesting new gene 3 protein, KIAA9001
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates p14-ARF (Homo sapiens)
Acetylated RUNX3 binds to BRD2 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
HDAC4 deacetylates RUNX3 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2):CDKN2A gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2):CDKN2A gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25440 BRD2
Gene Names
BRD2, KIAA9001, RING3
Chain
chain:1-801
Reference Genes
BioGPS Gene:6046 BRD2
COSMIC (genes):BRD2 BRD2
CTD Gene:6046 BRD2
dbSNP Gene:6046 BRD2
ENSEMBL:ENSG00000204256 BRD2
ENSEMBL:ENSG00000215077 BRD2
ENSEMBL:ENSG00000234507 BRD2
ENSEMBL:ENSG00000234704 BRD2
ENSEMBL:ENSG00000235307 BRD2
HGNC:1103 BRD2
KEGG Gene (Homo sapiens):6046 BRD2
Monarch:6046 BRD2
NCBI Gene:6046 BRD2
OMIM:601540 BRD2
UCSC:P25440 BRD2
Reference Transcript
RefSeq:NM_005104.3 BRD2
RefSeq:NM_001199455.1 BRD2
RefSeq:NM_001113182.2 BRD2
RefSeq:NM_001291986.1 BRD2
RefSeq:NM_001199456.1 BRD2
Other Identifiers
0006350484
11719629_a_at
11719630_a_at
17007326
17007349
17028381
17028404
17031209
17033678
17033701
17035950
17035966
17038661
17038684
17041292
17041315
208685_x_at
208686_s_at
214911_s_at
2903342
2903344
2903345
2903346
2903347
2903348
2903349
2903350
2903351
2903352
2903355
2903356
2903358
2903360
2903361
2903362
2903366
2903367
2903368
2903369
2903370
2903371
2903372
2903376
2903377
2903379
2903381
2903382
2903383
2903384
36208_at
36209_at
36210_g_at
6046
8118580
8179504
A_14_P103093
A_23_P256898
A_24_P307014
D42040_s_at
GE57200
GE83727
GO:0000003
GO:0001843
GO:0003674
GO:0003682
GO:0004674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0006325
GO:0006334
GO:0006357
GO:0006464
GO:0006468
GO:0007283
GO:0008150
GO:0009058
GO:0009790
GO:0010468
GO:0016032
GO:0016301
GO:0016607
GO:0022607
GO:0034641
GO:0042393
GO:0043226
GO:0044403
GO:0048646
GO:0048856
GO:0051276
GO:0065003
GO:0070577
HMNXSV003000811
HMNXSV003013254
HMNXSV003024890
Hs.75243.0.A1_3p_a_at
ILMN_1758918
PH_hs_0004295
S78771_s_at
TC06000406.hg
TC06000407.hg
TC06002732.hg
TC6_cox_hap2000097.hg
TC6_cox_hap2000098.hg
TC6_dbb_hap3000090.hg
TC6_mann_hap4000081.hg
TC6_mann_hap4000082.hg
TC6_mcf_hap5000082.hg
TC6_mcf_hap5000083.hg
TC6_qbl_hap6000088.hg
TC6_qbl_hap6000089.hg
TC6_ssto_hap7000083.hg
TC6_ssto_hap7000084.hg
X62083_s_at
Z84497_s_at
g577292_3p_a_at
Participates
as a component of
BRD2 homodimer [nucleoplasm] (Homo sapiens)
Inferred To
bet-1 [nucleoplasm]
(Caenorhabditis elegans)
fs(1)h [nucleoplasm]
(Drosophila melanogaster)
BRD2 [nucleoplasm]
(Bos taurus)
BRD2 [nucleoplasm]
(Canis familiaris)
BRD2 [nucleoplasm]
(Gallus gallus)
BRD2 [nucleoplasm]
(Sus scrofa)
brd2a [nucleoplasm]
(Danio rerio)
brd2 [nucleoplasm]
(Xenopus tropicalis)
Brd2 [nucleoplasm]
(Mus musculus)
Brd2 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001186385.1
,
NP_001186384.1
,
NP_001278915.1
,
NP_001106653.1
,
NP_005095.1
Guide to Pharmacology - Targets
1944
OpenTargets
ENSG00000204256
ZINC - Substances
BRD2_HUMAN
ZINC target
P25440
PRO
P25440
GlyGen
P25440
PDB
5XHK
,
5HEL
,
2YDW
,
7OE8
,
7NQI
,
6DB0
,
6ULQ
,
4A9M
,
5O39
,
5DFC
,
4UYF
,
4A9F
,
7NQ3
,
5O3D
,
1X0J
,
7OES
,
4ALH
,
2DVV
,
6Z8P
,
4MR6
,
7JX7
,
6Z7F
,
7NQ9
,
6MO7
,
4QEV
,
7NPZ
,
6K05
,
5O3H
,
3ONI
,
7OE6
,
5XHE
,
6JKE
,
6YTM
,
6I81
,
2DVS
,
5O38
,
5DFB
,
2E3K
,
4A9J
,
3AQA
,
7L9K
,
6SWP
,
4A9E
,
6K04
,
5O3G
,
7NQ2
,
4ALG
,
7OER
,
5O3C
,
5U6V
,
6FFG
,
4MR5
,
6ZB2
,
4J1P
,
7NQ8
,
5IBN
,
5HFQ
,
4QEU
,
6E6J
,
7NPY
,
7L6D
,
7OE5
,
5U5S
,
6MOA
,
6I80
,
5DW1
,
4A9I
,
2DVR
,
4UYH
,
7L9J
,
4AKN
,
5HEN
,
6SWO
,
5O3F
,
5EK9
,
7NQ1
,
5O3B
,
7OEP
,
6FFF
,
4A9O
,
6DDJ
,
6TQ2
,
6ONY
,
6ZB1
,
6MO9
,
5IG6
,
5BT5
,
7NQ7
,
2G4A
,
5HEM
,
7OE9
,
6ULT
,
7NQJ
,
5N2L
,
7OE4
,
6FFE
,
2DVQ
,
5DFD
,
6DDI
,
6DBC
,
4UYG
,
6U71
,
4A9H
,
6U8H
,
7OGY
,
6CUI
,
7OET
,
5O3E
,
7NQ0
,
4A9N
,
5O3A
,
2YEK
,
6TQ1
,
6ZB0
,
6U61
,
5UEW
,
6MO8
,
6VIY
,
4QEW
,
5O3I
,
7NQ5
HPA
ENSG00000204256-BRD2
GeneCards
P25440
Ensembl
ENST00000438194
,
ENST00000374825
,
ENSP00000382445
,
ENSG00000204256
,
ENSP00000382444
,
ENSP00000382443
,
ENSP00000449380
,
ENSP00000412885
,
ENSP00000449609
,
ENST00000442863
,
ENST00000449118
,
ENST00000399527
,
ENSP00000399009
,
ENSP00000391246
,
ENSP00000401791
,
ENSP00000405634
,
ENST00000399529
,
ENST00000399528
,
ENSG00000215077
,
ENST00000552587
,
ENSP00000410994
,
ENST00000374831
,
ENST00000449085
,
ENST00000383108
,
ENSP00000378702
,
ENSP00000372588
,
ENSP00000363958
,
ENST00000549126
,
ENST00000436979
,
ENST00000395287
,
ENSG00000235307
,
ENSP00000409145
,
ENST00000414731
,
ENSG00000234704
,
ENSP00000363964
,
ENST00000448067
,
ENSG00000234507
Pharos - Targets
P25440
ZINC - Predictions - Purchasable
BRD2_HUMAN
Orphanet
24375
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.599
8
UniProt:P62805 H4C1
17
HIST1H4A [extracellular region]
(R-HSA-977569)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
0.558
5
UniProt:P0DTC4 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9694754)
nascent E [endoplasmic reticulum lumen]
(R-COV-9694312)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694305)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694423)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9694465)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9694687)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698422)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698416)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698420)
0.527
2
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