Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BRD2 [nucleoplasm]
Stable Identifier
R-HSA-8951979
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Bromodomain-containing protein 2, RING3, Really interesting new gene 3 protein, KIAA9001
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates p14-ARF (Homo sapiens)
Acetylated RUNX3 binds to BRD2 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
HDAC4 deacetylates RUNX3 (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2):CDKN2A gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2):CDKN2A gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm] (Homo sapiens)
BRD2 homodimer [nucleoplasm] (Homo sapiens)
BRD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25440 BRD2
Gene Names
BRD2, KIAA9001, RING3
Chain
chain:1-801
Reference Genes
BioGPS Gene:6046 BRD2
COSMIC (genes):BRD2 BRD2
CTD Gene:6046 BRD2
dbSNP Gene:6046 BRD2
ENSEMBL:ENSG00000204256 BRD2
HGNC:1103 BRD2
KEGG:hsa:6046 BRD2
Monarch:6046 BRD2
NCBI Gene:6046 BRD2
OMIM:601540 BRD2
UCSC:P25440 BRD2
Reference Transcript
RefSeq:NM_001113182.3 BRD2
RefSeq:NM_001199456.2 BRD2
RefSeq:NM_005104.4 BRD2
RefSeq:NM_001199455.1 BRD2
RefSeq:NM_001291986.2 BRD2
Other Identifiers
11719629_a_at
11719630_a_at
17007326
17007349
17028381
17028404
17031209
17033678
17033701
17035950
17035966
17035969
17038661
17038684
17041292
17041315
208685_PM_x_at
208685_x_at
208686_PM_s_at
208686_s_at
214911_PM_s_at
214911_s_at
2903342
2903344
2903345
2903346
2903347
2903348
2903349
2903350
2903351
2903352
2903353
2903354
2903355
2903356
2903357
2903358
2903359
2903360
2903361
2903362
2903363
2903364
2903365
2903366
2903367
2903368
2903369
2903370
2903371
2903372
2903373
2903374
2903375
2903376
2903377
2903378
2903379
2903381
2903382
2903383
2903384
36208_at
36209_at
36210_g_at
6046
8118580
8179504
A_14_P103093
A_23_P256898
A_24_P307014
D42040_s_at
GE57200
GE83727
GO:0000785
GO:0001843
GO:0003682
GO:0003824
GO:0004674
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006325
GO:0006334
GO:0006338
GO:0006355
GO:0006357
GO:0007283
GO:0010468
GO:0016607
GO:0016740
GO:0022414
GO:0042393
GO:0043226
GO:0060090
GO:0065003
GO:0070577
GO:0071168
GO:0140033
GO:0140096
GO:0140566
GO:0140588
GO:2000330
HMNXSV003000811
HMNXSV003013254
HMNXSV003024890
Hs.75243.0.A1_3p_a_at
ILMN_1758918
PH_hs_0004295
S78771_s_at
TC06000406.hg
TC06000407.hg
TC06002732.hg
TC6_cox_hap2000097.hg
TC6_cox_hap2000098.hg
TC6_dbb_hap3000090.hg
TC6_mann_hap4000081.hg
TC6_mann_hap4000082.hg
TC6_mcf_hap5000082.hg
TC6_mcf_hap5000083.hg
TC6_mcf_hap5000084.hg
TC6_qbl_hap6000088.hg
TC6_qbl_hap6000089.hg
TC6_ssto_hap7000083.hg
TC6_ssto_hap7000084.hg
X62083_s_at
Z84497_s_at
g577292_3p_a_at
p14531
Participates
as a component of
BRD2 homodimer [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of BRD2 [nucleoplasm]
(Bos taurus)
Ghost homologue of BRD2 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of BRD2 [nucleoplasm]
(Canis familiaris)
Ghost homologue of BRD2 [nucleoplasm]
(Gallus gallus)
Ghost homologue of BRD2 [nucleoplasm]
(Mus musculus)
Ghost homologue of BRD2 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of BRD2 [nucleoplasm]
(Sus scrofa)
fs(1)h [nucleoplasm]
(Drosophila melanogaster)
Homologues of BRD2 [nucleoplasm]
(Drosophila melanogaster)
tbrd-1 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005095.1
,
NP_001186385.1
,
NP_001278915.1
,
NP_001186384.1
,
NP_001106653.1
Guide to Pharmacology - Targets
1944
OpenTargets
ENSG00000204256
ENSEMBL
ENSP00000502900
,
ENSG00000204256
,
ENSP00000449609
,
ENST00000374831
,
ENSP00000382443
,
ENSP00000382445
,
ENSP00000382444
,
ENSP00000372588
,
ENSG00000234704
,
ENSG00000234507
,
ENSP00000363964
,
ENSP00000399009
,
ENSP00000412885
,
ENSP00000449380
,
ENST00000552587
,
ENSP00000378702
,
ENSG00000215077
,
ENST00000436979
,
ENST00000438194
,
ENST00000395287
,
ENST00000449085
,
ENSP00000409145
,
ENST00000383108
,
ENST00000399527
,
ENST00000399528
,
ENST00000399529
,
ENSP00000363958
,
ENSG00000235307
,
ENST00000374825
,
ENSP00000410994
,
ENST00000549126
,
ENST00000442863
,
ENSP00000391246
,
ENSP00000405634
,
ENST00000449118
,
ENSP00000401791
,
ENST00000414731
,
ENST00000448067
,
ENST00000678250
ZINC - Substances
BRD2_HUMAN
ZINC target
P25440
PRO
P25440
GlyGen
P25440
PDB
6DDI
,
5DFB
,
7NQ7
,
6ZB1
,
7WLN
,
4ALG
,
7OE8
,
7NQ1
,
8B5I
,
4QEU
,
5DW1
,
7OES
,
6U8H
,
6MO7
,
5O3G
,
2YDW
,
5IBN
,
6ULT
,
8PX8
,
4A9E
,
6DBC
,
6K05
,
5HFQ
,
5IG6
,
5O3E
,
5EK9
,
5DFD
,
7NQJ
,
4A9J
,
5S9O
,
6E6J
,
4UYF
,
8CV7
,
4UYH
,
8Z69
,
9FBX
,
7VRQ
,
5O3D
,
1X0J
,
4ALH
,
7OE5
,
8B5H
,
6Z7F
,
6ZB0
,
4AKN
,
7NQ9
,
6I81
,
5U5S
,
5O3B
,
6ULQ
,
7EO5
,
6JKE
,
7WMQ
,
5XHE
,
7NQ2
,
4A9F
,
6FFE
,
7UU0
,
4A9O
,
6FFG
,
6K04
,
2DVV
,
5O3F
,
4A9M
,
5O39
,
7USG
,
6MO9
,
6SWP
,
4UYG
,
4A9I
,
7L9J
,
5UEW
,
8PX2
,
7NPY
,
7VRO
,
4J1P
,
5U6V
,
4QEV
,
7USH
,
6U61
,
5O3I
,
8B5J
,
2G4A
,
7OE6
,
5XHK
,
8DNQ
,
6DDJ
,
7JX7
,
7L6D
,
7Q5O
,
5O3A
,
7ENV
,
7VSF
,
7OET
,
5O3H
,
7OE9
,
7OER
,
7NQ3
,
7OE4
,
7VRK
,
5HEN
,
5HEM
,
6Z8P
,
7WMU
,
6ZB2
,
6MO8
,
4MR6
,
2YEK
,
6MOA
,
6SWO
,
7L9K
,
7NPZ
,
4A9H
,
6YTM
,
7ENZ
,
6CUI
,
6TQ2
,
8WYG
,
2DVR
,
7VS0
,
2E3K
,
7VRH
,
7WNA
,
5O3C
,
3ONI
,
5N2L
,
7OEP
,
5BT5
,
7WNI
,
8B5G
,
3AQA
,
6I80
,
7USI
,
7NQ0
,
6VIY
,
7NQ8
,
7LAK
,
7DPO
,
8SB6
,
7WN5
,
7NQ5
,
7VRZ
,
6U71
,
2DVS
,
7VRM
,
5HEL
,
6FFF
,
4A9N
,
5DFC
,
7DPN
,
4QEW
,
7NQI
,
7L9G
,
6DB0
,
7OGY
,
4MR5
,
6WWB
,
5O38
,
6ONY
,
6TQ1
,
7VRI
,
2DVQ
,
7VS1
GeneCards
BRD2
HPA
ENSG00000204256-BRD2
Pharos - Targets
P25440
ZINC - Predictions - Purchasable
BRD2_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67870 CSNK2B
5
CSNK2B [cytosol]
(R-HSA-201693)
CSNK2B [nucleoplasm]
(R-HSA-6805067)
CSNK2B [ficolin-1-rich granule lumen]
(R-HSA-6801290)
CSNK2B [extracellular region]
(R-HSA-6806508)
CSNK2B [secretory granule lumen]
(R-HSA-6801319)
0.643
3
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.599
8
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.558
5
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.527
2
UniProt:P0DTC4 E
9
Ub-3xPalmC-E [virion membrane]
(R-COV-9698416)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698422)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698420)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9694687)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9694465)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694423)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694305)
nascent E [endoplasmic reticulum lumen]
(R-COV-9694312)
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9694754)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text