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RUNX3 binds the RUNX1 promoter
Stable Identifier
R-HSA-8951910
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates RUNX1-mediated transcription (Homo sapiens)
RUNX3 binds the RUNX1 promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RUNX3, presumably associated with CBFB, binds Runx response elements in the distal (P1) promoter of the RUNX1 gene (Spender et al. 2005). All RUNX family members contain Runx response elements in their promoters (Levanon and Groner 2004).
Literature References
PubMed ID
Title
Journal
Year
15688019
Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells
Whiteman, HJ
,
Spender, LC
,
Karstegl, CE
,
Farrell, PJ
Oncogene
2005
Participants
Input
RUNX1 gene [nucleoplasm]
(Homo sapiens)
RUNX3:CBFB [nucleoplasm]
(Homo sapiens)
Output
RUNX3:CBFB:RUNX1 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RUNX3 regulates RUNX1-mediated transcription (Homo sapiens)
Authored
Orlic-Milacic, M (2016-12-13)
Reviewed
Ito, Y (2017-01-31)
Chuang, LS (2017-01-31)
Created
Orlic-Milacic, M (2016-12-12)
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