TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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The 18 kDa translocator protein (TSPO), originally identified as a peripheral-type benzodiazepine receptor (BZRP), is a drug- and cholesterol-binding protein found at particularly high levels in steroid synthesising cells such as those of the adrenal glands and testes (Lin et al. 1993, De Souza et al. 1985). TSPO is localised to the outer mitochondrial membrane (Anholt et al. 1986) and could facilitate the transport of cholesterol (CHOL) to the inner mitochondrial membrane where the first step of steroidogenesis occurs (review - Papadopoulos et al. 2015). The peripheral-type benzodiazepine receptor-associated protein 1 (TSPOAP1, aka BZRAP1, PRAX1) is a cytosolic protein that specifically interacts with TSPO (Galiegue et al. 1993) but its role is undetermined.

Literature References
PubMed ID Title Journal Year
2981667 Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis

Anholt, RR, Murphy, KM, Kuhar, MJ, De Souza, EB, Snyder, SH

Endocrinology 1985
8307574 The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia

Miller, WL, Chang, YJ, Lin, D, Strauss, JF

Genomics 1993
9915832 Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor

Bribes, E, Gali├Ęgue, S, Le Fur, G, Casellas, P, Combes, T, Jbilo, O, Carayon, P

J. Biol. Chem. 1999
25818881 Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis

Papadopoulos, V, Campioli, E, Fan, J, Aghazadeh, Y, Midzak, A, Zirkin, B

Mol. Cell. Endocrinol. 2015
3001071 The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane

Pedersen, PL, Anholt, RR, De Souza, EB, Snyder, SH

J. Biol. Chem. 1986
Catalyst Activity

cholesterol transfer activity of TSPO:BZRAP1 [mitochondrial outer membrane]

Orthologous Events
Cross References
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