TEADs:YAP1 binds CTGF gene

Stable Identifier
R-HSA-8951695
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TEADs:YAP1 binds CTGF gene
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The complex of YAP1 and one TEAD proteins (TEAD1, TEAD2, TEAD3 or TEAD4) binds to TEAD-binding sites in the promoter of the CTGF gene (Zhao et al. 2008). Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter (Qiao et al. 2016).
Literature References
PubMed ID Title Journal Year
18579750 TEAD mediates YAP-dependent gene induction and growth control

Zhao, B, Ye, X, Yu, J, Li, L, Li, W, Li, S, Yu, J, Lin, JD, Wang, CY, Chinnaiyan, AM, Lai, ZC, Guan, KL

Genes Dev. 2008
26364597 RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer

Qiao, Y, Lin, SJ, Chen, Y, Voon, DC, Zhu, F, Chuang, LS, Wang, T, Tan, P, Lee, SC, Yeoh, KG, Sudol, M, Ito, Y

Oncogene 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] (Homo sapiens)
Active Unit
RUNX3:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-09)
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