TEADs:YAP1 binds CTGF gene

Stable Identifier
Reaction [binding]
Homo sapiens
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The complex of YAP1 and one TEAD proteins (TEAD1, TEAD2, TEAD3 or TEAD4) binds to TEAD-binding sites in the promoter of the CTGF gene (Zhao et al. 2008). Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter (Qiao et al. 2016).

Literature References
PubMed ID Title Journal Year
18579750 TEAD mediates YAP-dependent gene induction and growth control

Guan, KL, Yu, J, Li, L, Li, S, Li, W, Ye, X, Chinnaiyan, AM, Wang, CY, Lai, ZC, Yu, J, Zhao, B, Lin, JD

Genes Dev. 2008
26364597 RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer

Tan, P, Lin, SJ, Voon, DC, Chuang, LS, Yeoh, KG, Wang, T, Qiao, Y, Sudol, M, Ito, Y, Lee, SC, Chen, Y, Zhu, F

Oncogene 2016
This event is regulated