Release of mature NEDD8

Stable Identifier
R-HSA-8951644
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
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Release of mature NEDD8
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After C-terminal processing by UCHL3 or SENP8, mature NEDD8 is released (Wada et al, 1998; Wu et al, 2003).

Literature References
PubMed ID Title Journal Year
12759363 DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1

Wu, K, Yamoah, K, Dolios, G, Gan-Erdene, T, Tan, P, Chen, A, Lee, CG, Wei, N, Wilkinson, KD, Wang, R, Pan, ZQ

J. Biol. Chem. 2003
9790970 Cleavage of the C-terminus of NEDD8 by UCH-L3

Wada, H, Kito, K, Caskey, LS, Yeh, ET, Kamitani, T

Biochem. Biophys. Res. Commun. 1998
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Orthologous Events
Release of mature NEDD8 (Caenorhabditis elegans)
Release of mature NEDD8 (Canis familiaris)
Release of mature NEDD8 (Danio rerio)
Release of mature NEDD8 (Dictyostelium discoideum)
Release of mature NEDD8 (Drosophila melanogaster)
Release of mature NEDD8 (Gallus gallus)
Release of mature NEDD8 (Mus musculus)
Release of mature NEDD8 (Plasmodium falciparum)
Release of mature NEDD8 (Rattus norvegicus)
Release of mature NEDD8 (Saccharomyces cerevisiae)
Release of mature NEDD8 (Schizosaccharomyces pombe)
Release of mature NEDD8 (Sus scrofa)
Release of mature NEDD8 (Xenopus tropicalis)
Authored
Rothfels, K  (2016-12-13)
Reviewed
Pick, E  (2017-02-22)
Created
Rothfels, K  (2016-12-08)
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