CALR, TAP, TAPBP dissociate from SEC22B:STX4

Stable Identifier
R-HSA-8951595
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane, phagocytic vesicle membrane
ReviewStatus
5/5
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CALR, TAP, TAPBP dissociate from SEC22B:STX4
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The interaction between the two compartments involves either direct fusion of ER stacks to phagosomes (Phgs) or vesicular intermediates. In both cases, a fusion event between the ER or ER-derived membrane vesicles and Phgs must occur. The SNARE SEC22B localizes to the ER-Golgi intermediate compartment (ERGIC) and interacts with SNARE syntaxin 4 (STX4) on phagosomes (Phgs), mediating the recruitment of subset of ER components including transporter associated with antigen processing (TAP), to phagosomes (Cebrian et al. 2011).
Literature References
PubMed ID Title Journal Year
22153078 Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells

Savina, A, Amigorena, S, Blanchard, N, Moita, LF, Moita, C, Visentin, G, Jouve, M, Bobard, A, Cebrian, I, Enninga, J

Cell 2011
Participants
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Output
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as an event of
Event Information
Go Biological Process
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane (1990668)
Orthologous Events
CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Bos taurus)
CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Mus musculus)
CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Rattus norvegicus)
CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Sus scrofa)
Authored
Garapati, P V  (2016-03-10)
Reviewed
Bergeron, JJ  (2016-05-16)
Created
Jupe, S  (2016-12-08)
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