p-VAV family:PIP3 binds RAC1:GDP

Stable Identifier
R-HSA-8951586
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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p-VAV family:PIP3 binds RAC1:GDP
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Tyrosine-phosphorylated VAVs bind RAC1:GDP as RAC1 guanine nucleotide exchange factors (GEFs), catalysing the exchange of bound GDP for GTP. RAC1 is a key regulator for actin cytoskeleton and cell migration and is also a critical component of endothelial NADPH oxidase (Wittmann et al. 2003, Tan et al. 2008, Ushio–Fukai 2007, Price et al. 2002).
Literature References
PubMed ID Title Journal Year
17686471 VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

Burridge, K, Van Buul, JD, Garrett, TA

Exp. Cell Res. 2007
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Orthologous Events
p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)
p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)
p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)
p-VAV family:PIP3 binds RAC1:GDP (Drosophila melanogaster)
p-VAV family:PIP3 binds RAC1:GDP (Gallus gallus)
p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)
p-VAV family:PIP3 binds RAC1:GDP (Rattus norvegicus)
p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)
p-VAV family:PIP3 binds RAC1:GDP (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Jupe, S  (2016-12-08)
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