p-VAV family:PIP3 binds RAC1:GDP

Stable Identifier
R-HSA-8951586
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Tyrosine-phosphorylated VAVs bind RAC1:GDP as RAC1 guanine nucleotide exchange factors (GEFs), catalysing the exchange of bound GDP for GTP. RAC1 is a key regulator for actin cytoskeleton and cell migration and is also a critical component of endothelial NADPH oxidase (Wittmann et al. 2003, Tan et al. 2008, Ushio–Fukai 2007, Ushio–Fukai et al. 2002).

Literature References
PubMed ID Title Journal Year
17686471 VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

Garrett, TA, Van Buul, JD, Burridge, K

Exp. Cell Res. 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created