CD46 binds C4b

Stable Identifier
R-HSA-8951486
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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CD46 binds C4b
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Membrane cofactor protein (MCP; CD46) is a widely distributed cell surface glycoprotein that can bind C3b and C4b, which are cofactors for Complement factor I.

Literature References
PubMed ID Title Journal Year
2481448 Functional properties of membrane cofactor protein of complement

Seya, T, Atkinson, JP

Biochem J 1989
12055245 Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells

Barilla-LaBarca, ML, Liszewski, MK, Lambris, JD, Hourcade, D, Atkinson, JP

J Immunol 2002
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Orthologous Events
CD46 binds C4b (Bos taurus)
CD46 binds C4b (Caenorhabditis elegans)
CD46 binds C4b (Canis familiaris)
CD46 binds C4b (Danio rerio)
CD46 binds C4b (Drosophila melanogaster)
CD46 binds C4b (Gallus gallus)
CD46 binds C4b (Mus musculus)
CD46 binds C4b (Rattus norvegicus)
CD46 binds C4b (Sus scrofa)
CD46 binds C4b (Xenopus tropicalis)
Authored
Jupe, S  (2010-11-09)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2016-12-07)
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