CD46 binds C4b

Stable Identifier
R-HSA-8951486
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CD46 binds C4b
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Membrane cofactor protein (MCP; CD46) is a widely distributed cell surface glycoprotein that can bind C3b and C4b, which are cofactors for Complement factor I.

Literature References
PubMed ID Title Journal Year
12055245 Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells

Atkinson, JP, Barilla-LaBarca, ML, Lambris, JD, Liszewski, MK, Hourcade, D

J Immunol 2002
2481448 Functional properties of membrane cofactor protein of complement

Atkinson, JP, Seya, T

Biochem J 1989
Participants
Input
Output
Participates
as an event of
Orthologous Events
CD46 binds C4b (Bos taurus)
CD46 binds C4b (Canis familiaris)
CD46 binds C4b (Danio rerio)
CD46 binds C4b (Drosophila melanogaster)
CD46 binds C4b (Gallus gallus)
CD46 binds C4b (Mus musculus)
CD46 binds C4b (Rattus norvegicus)
CD46 binds C4b (Sus scrofa)
CD46 binds C4b (Xenopus tropicalis)
Authored
Jupe, S  (2010-11-09)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2016-12-07)
Cite Us!