IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2

Stable Identifier
R-HSA-8951178
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Summation

Experimental evidence in samples of patients with AML, shows that 32D myeloid cells transformed by IL-27RA (subunit which can be part of the Interleukin-35 receptor or Interleukin-27 receptor) contain elevated levels of activated forms of various signaling proteins incluiding Jak1, Jak2, Stat1, Stat3, (PMID:18003935).

Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA

Nat. Immunol. 2012
18003935 Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor

Pradhan, A, Lambert, QT, Reuther, GW

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
components
Participant Of
hasComponent
Inferred To
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Bos taurus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Danio rerio)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Gallus gallus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Mus musculus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Sus scrofa)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Xenopus tropicalis)