Reactome | p-Y705-STAT3 binds p-Y693-STAT4

p-Y705-STAT3 binds p-Y693-STAT4

Stable Identifier

R-HSA-8950780

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Interleukin-23 (IL23) signaling predominantly leads to formation of Signal transducer and activator of transcription 3 (STAT3) homodimers while also heterodimers of STAT3 and STAT4 can also be formed (Parham et al. 2002). The STAT4 phosphorylation induced by IL23 is much weaker than induced in response to Interleukin-12.

Literature References

PubMed ID	Title	Journal	Year
12023369	A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R Vaisberg, E, Wagner, J, Gorman, D, Singh, KP, Travis, M, Parham, C, To, W, Zhang, R, Kastelein, RA, Zurawski, S, Cheung, J, McClanahan, T, O'Farrell, AM, Timans, J, Pflanz, S, Rennick, DM, Vega, F, Moore, KW, de Waal Malefyt, R, Hannum, C, Chirica, M	J Immunol	2002
19161421	From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited Boniface, K, de Waal Malefyt, R, Liu, YJ, Blom, B	Immunol. Rev.	2008