p-Y705-STAT3 binds p-Y693-STAT4

Stable Identifier
Reaction [binding]
Homo sapiens
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Interleukin-23 (IL23) signaling predominantly leads to formation of Signal transducer and activator of transcription 3 (STAT3) homodimers while also heterodimers of STAT3 and STAT4 can also be formed (Parham et al. 2002). The STAT4 phosphorylation induced by IL23 is much weaker than induced in response to Interleukin-12.

Literature References
PubMed ID Title Journal Year
12023369 A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

Vaisberg, E, Wagner, J, Gorman, D, Singh, KP, Travis, M, Parham, C, To, W, Zhang, R, Kastelein, RA, Zurawski, S, Cheung, J, McClanahan, T, O'Farrell, AM, Timans, J, Pflanz, S, Rennick, DM, Vega, F, Moore, KW, de Waal Malefyt, R, Hannum, C, Chirica, M

J Immunol 2002
19161421 From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

Boniface, K, de Waal Malefyt, R, Liu, YJ, Blom, B

Immunol. Rev. 2008
Orthologous Events
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