IL12A:IL12B translocates from Golgi lumen to late endosome lumen

Stable Identifier
R-HSA-8950752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-12 translocates from Golgi lumen to late endosome lumen
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Inferred from mouse:
Interleukin-12 (IL12) translocates from the Golgi to the late endosome.

IL12 has been localized in late endocytic vesicles identified by the marker protein Vesicle-associated membrane protein 7 (VAMP7).
Immunoelectron microscopy on cells expressing p35-SV5 (recombinant murine Il12a with simian virus 5) revealed that the majority of Il12a was associated with Golgi stacks and nearby tubovesicular membranes representing the trans-Golgi Network (Chiaruttini et al. 2016). A fraction of the protein was contained in vesicles and tubules associated with late-endosomes/lysosomes. This indicates that post-golgi trafficking of bioactive IL12 in dendritic cells utilizes late endocytic vesicles.

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