Inferred from mouse:
Interleukin-12 (IL12) translocates from the Golgi to the late endosome.
IL12 has been localized in late endocytic vesicles identified by the marker protein Vesicle-associated membrane protein 7 (VAMP7).
Immunoelectron microscopy on cells expressing p35-SV5 (recombinant murine Il12a with simian virus 5) revealed that the majority of Il12a was associated with Golgi stacks and nearby tubovesicular membranes representing the trans-Golgi Network (Chiaruttini et al. 2016). A fraction of the protein was contained in vesicles and tubules associated with late-endosomes/lysosomes. This indicates that post-golgi trafficking of bioactive IL12 in dendritic cells utilizes late endocytic vesicles.