IL12B:IL23A translocates from ER lumen to extracellular space

Stable Identifier
R-HSA-8950741
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-23 traslocates to the extracellular space, IL23A:IL12B complex is traslocated to the extracellular space, Interleukin-23A:Interleukin-12B complex is traslocated to the extracellular space.
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Interleukin-23 is secreted to the extracellular region.

T helper 1 cell (Th1) cytokines such as Interferon-gamma (IFNG) and Interleukin-12 (IL12) are transported through the tubulovesicular system to small secretory vesicles from their sites of storage in crystalloid granules (Spencer et al. 2009, Melo et al. 2005). In neutrophils the precise intracellular location of cytokines and chemokines is unknown, although histological examination of mature peripheral neutrophils suggests that Interleukin-6, IL12 and C-X-C motif chemokine 2 (CXCL2) may be stored within secretory vesicles or tertiary granules (Denkers et al. 2003, Stanley & Lacy 2010).

This reaction is a black box event because we know this Interleukin-23 heterodimeric protein is secreted but do not know the storage compartment and mechanism involved in the traslocation.

Literature References
PubMed ID Title Journal Year
16138901 Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils

Melo, RC, Perez, SA, Spencer, LA, Dvorak, AM, Weller, PF

Traffic 2005
18840671 Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially

Spencer, LA, Szela, CT, Perez, SA, Kirchhoffer, CL, Neves, JS, Radke, AL, Weller, PF

J. Leukoc. Biol. 2009
20699468 Pathways for cytokine secretion

Stanley, AC, Lacy, P

Physiology (Bethesda) 2010
12947981 Neutrophil production of IL-12 and other cytokines during microbial infection

Denkers, EY, Del Rio, L, Bennouna, S

Chem Immunol Allergy 2003
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