JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated

Stable Identifier
R-HSA-8950591
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
JAK2 and TYK2 activation after IL23:IL23R interaction
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In human cells IL-23 binding leads to phosphorylation and activation of TYK2 and JAK2 (Parham et al 2002). Inferred from mouse:
The intracellular domain of Interleukin 12 receptor beta 1 subunit (Il12rb1), spanning amino acid residues 592–656, is crucial for Interleukin 23 complex–induced cellular proliferation and Signal transducer and activator of transcription 3 (Stat3) phosphorylation (Floss et al. 2016).
As it is not clear what induces JAK2 and TYK2 kinase phosphorylation this is represented here as a black box event.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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