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IL12RB1:p-Y-TYK2
Stable Identifier
R-HSA-8950587
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
27193299
Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases
Mol. Biol. Cell
2016
Participants
components
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
Participant Of
hasComponent
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane]
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane]
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane]
Inferred To
IL12RB1:p-Y-TYK2 [plasma membrane] (Bos taurus)
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL12RB1:p-Y-TYK2 [plasma membrane] (Danio rerio)
IL12RB1:p-Y-TYK2 [plasma membrane] (Gallus gallus)
IL12RB1:p-Y-TYK2 [plasma membrane] (Mus musculus)
IL12RB1:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
IL12RB1:p-Y-TYK2 [plasma membrane] (Sus scrofa)
IL12RB1:p-Y-TYK2 [plasma membrane] (Xenopus tropicalis)
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