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STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
Stable Identifier
R-HSA-8950583
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
Synonyms
STAT3 binds to IL23R from IL23:IL23 receptor
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
General
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Inferred from mouse :
Signal transducer and activator of transcription 3 (STAT3) binds tyrosine residues of the Interleukin-23 receptor (IL23R) after cytokine-receptor interaction (Dumoutier et al. 2009, Floss et al. 2013). This is a black box event because STAT3 binding as a consequence of Interleukin-23 stimulation has not been directly demonstrated. IL23R can also bind STAT4, this alternative binding is not represented here only because the evidence for STAT3 binding is inferred from mouse/human chimeras while STAT4 binding evidence was obtained with human protein data.
Participants
Input
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane]
(Homo sapiens)
STAT3 [cytosol]
(Homo sapiens)
Output
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-23 signaling (Homo sapiens)
Inferred From
Stat3 binds to p-Y-Il23r from Il23:Il23 receptor (Mus musculus)
Authored
Duenas, C (2016-12-02)
Reviewed
van de Vosse, E (2017-05-12)
Created
Duenas, C (2016-12-02)
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