IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane]

Stable Identifier
R-HSA-8950547
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General

Signal transducer and activator of transcription 3 (Stat3) binds Interleukin-23 receptor (Il23r), after cytokine-receptor interaction, for both canonical and non-canonical Stat3 activation (Dumoutier et al. 2009, Floss et al. 2013). This is a black box event because Stat3 binding as a consequence of Interleukin-23 stimulation has not been directly demonstrated.

Literature References
PubMed ID Title Journal Year
23673666 Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor

Floss, DM, Mrotzek, S, Klöcker, T, Schröder, J, Grötzinger, J, Rose-John, S, Scheller, J

J. Biol. Chem. 2013
Participants
components
Participant Of
output
hasComponent
input
Inferred From
Stat3:Il23a:Il12b:Il12rb1:p-Tyk2:p-Y542,p-Y622,p-Il23r:p-Jak2 [plasma membrane] (Mus musculus)
Inferred To
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Danio rerio)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Mus musculus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Rattus norvegicus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Sus scrofa)