Signal transducer and activator of transcription 3 (Stat3) binds Interleukin-23 receptor (Il23r), after cytokine-receptor interaction, for both canonical and non-canonical Stat3 activation (Dumoutier et al. 2009, Floss et al. 2013). This is a black box event because Stat3 binding as a consequence of Interleukin-23 stimulation has not been directly demonstrated.
Floss, DM, Mrotzek, S, Klöcker, T, Schröder, J, Grötzinger, J, Rose-John, S, Scheller, J
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