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STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
Stable Identifier
R-HSA-8950448
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
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Signal transducer and activator of transcription 4 (STAT4) binds to phosphorylated tyrosine-800 and a few surronding amino acids on Interleukin-12 receptor subunit beta 2 (IL12RB2) (Yao et al. 1999).
Literature References
PubMed ID
Title
Journal
Year
10415122
Direct interaction of STAT4 with the IL-12 receptor
Yao, BB
,
Faltynek, CR
,
Surowy, CS
,
Niu, P
Arch. Biochem. Biophys.
1999
Participants
Input
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane]
(Homo sapiens)
x 2
STAT4 [cytosol]
(Homo sapiens)
Output
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-12 signaling (Homo sapiens)
Orthologous Events
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Bos taurus)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Mus musculus)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Sus scrofa)
Authored
Duenas, C (2016-12-02)
Reviewed
van de Vosse, E (2017-05-12)
Created
Duenas, C (2016-12-02)
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