Reactome | IL12B:IL12B translocates from ER lumen to the extracellular region

IL12B:IL12B translocates from ER lumen to the extracellular region

Stable Identifier

R-HSA-8950410

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, extracellular region

Synonyms

Interleukin-12 subunit beta homodimer traslocates to the extracellular region

ReviewStatus

5/5

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IL12B:IL12B translocates from ER lumen to the extracellular region

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Interleukin-12 subunit beta (IL12B, IL-12p40) can form oligomers with other interleukin subunits or be secreted as a monomer to the extracellular region (Ling et al. 1995).
Production of human IL12B homodimers has only been detected in cells with IL-12p40 expression constructs (Ling et al 1995, Alloza & Vandenbroeck 2015), not in natural conditions (Carra et al 2000).

Literature References

PubMed ID	Title	Journal	Year
7527811	Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity Stern, AS, Hollfelder, K, Su, C, Hakimi, J, Gubler, U, Gately, MK, Lin, P, Pan, YC, Ling, P	J. Immunol.	1995
15720785	The metallopeptide antibiotic bacitracin inhibits interleukin-12 alphabeta and beta2 secretion Vandenbroeck, K, Alloza, I	J. Pharm. Pharmacol.	2005